Informations générales
Intitulé de l'offre : M/F - post doc - THE ROLE OF PULSATILITY IN THE MORPHOGENESIS OF JELLYFISH CANAL NETWORKS (H/F)
Référence : UMR7057-CARPHI-033
Nombre de Postes : 1
Lieu de travail : PARIS 13
Date de publication : jeudi 3 juillet 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 12 mois
Date d'embauche prévue : 1 septembre 2025
Quotité de travail : Complet
Rémunération : Between 3080 € et 4 756 € according to experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
Section(s) CN : 54 - Phénomènes fondamentaux et propriétés collectives du vivant : développements instrumentaux, expériences et modèles physiques
Missions
The mission of the postdoc is to study the role of pulsatility in the formation of loops in networks. Many models explain the formation of branched networks, but only few can explain reticulated ones. Some theoretical investigations show that the reversal of flows favors the presence of loops. Here the question is to look if pulsatility affects morphogenesis and supports the presence of loops in vascular networks of biological systems. We will use Aurelia jellyfish as an experimental model. The scyphozoan jellyfish Aurelia belongs to the cnidarian, which is an ancient phylum considered a sister group to all bilaterian animals, including mammals. Common mechanisms found in jellyfish and mammals will highlight their universality possibly applying to their common ancestor and it descendants.
Activités
In Aurelia jellyfish you will study how the pulsatile flow in the canals is generated by cilia movements and squeezing of the deformable canals by the swimming muscle. During development you will study how canal network morphogenesis is affected by pulsatility by interventions that include changing the propagation of the flow pulsatility or impairing the pulsatility generated by the swimming. Complementary, you will help to study how pulsatility is playing a role in the morphogenesis of canal networks with topologies akin to arterial malformations (MVAs), defects due to the creation of shortcuts between veins and arteries that occur in patients when the blood pulsatility is suppressed with an implanted constant flow pump.
Compétences
Candidates with a background in biophysics are preferred. Candidates with experience in image analysis (e.g. particle image velocimetry, segmentation) are welcome.
Contexte de travail
The current position is situated within a consortium for a Human Frontiers Science Program project, which includes an experimental cardiovascular biologist at the University of Leuven (E. Jones, Belgium) and a theoretical physicist at the University of Pennsylvania (E. Katifori, USA). Funding for the position is available for 1 year. The postion can be extended for a further 1 year depending on possibilities and contingent on satisfactory progress.
Contraintes et risques
For the breeding of jellyfish sometimes it is necessary to feed them during the weekends