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Portail > Offres > Offre UMR7057-CARPHI-010 - Ingénieur (H/F) - - Développement d'une formulation contenant des vésicules extracellulaires et un hydrogel

Engineer (M/F) - - Development of a formulation containing extracellular vesicles and a hydrogel

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 1 décembre 2020

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General information

Reference : UMR7057-CARPHI-010
Workplace : PARIS 06
Date of publication : Tuesday, November 10, 2020
Type of Contract : FTC Technical / Administrative
Contract Period : 12 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : CNRS gross salary between 2510 and 2890 euros depending on experience
Desired level of education : Higher than 5-year university degree
Experience required : Over 10 years

Missions

Extracellular vesicles (EVs), especially mesenchymal stem cells (MSCs), play a direct role in restoring tissue function and homeostasis. These EVs are increasingly seen as competent effectors as an alternative to cells for regenerative medicine in a paradigm shift from cell therapy to sub-cellular therapy (EV). The implementation of the protocol for the production of EVs in bioreactors compatible with Good Manufacturing Practices (GMP) is a major challenge in the implementation of EV MSC production.

Activities

We intend to set up a culture of MSCs in stirred tank GMP bioreactors to produce EVs. In addition, we will develop a formulation based on the resulting vesicles combined with a hydrogel and test their immunomodulatory effect in vitro and in vivo.

Skills

Required skills :
- production of adherent cells in agitated tank type bioreactors,
- production of extracellular vesicles and their characterization,
- in vitro and in vivo immuno-modulation tests

Education: Pharmacist

Work Context

The person recruited will benefit from an internationally renowned interdisciplinary environment at the MSC laboratory, renowned for its expertise in the field of biophysics.

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