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Reference : UMR6074-DOMLAV-002
Workplace : RENNES
Date of publication : Tuesday, June 8, 2021
Type of Contract : FTC Technical / Administrative
Contract Period : 24 months
Expected date of employment : 12 July 2021
Proportion of work : Full time
Remuneration : between 2088 and 2400 Euros gross per month depending on experience
Desired level of education : 5-year university degree
Experience required : Indifferent
The mission of the Research Engineer is part of the dnarXiv project (https://project.inria.fr/dnarxiv/). His/her mission will be to develop all the biological approaches upstream and downstream of the dnarXiv program. That is to say, to develop upstream, the long synthesis of DNA. On the downstream side, the IE will be responsible for sequencing the molecules produced by the Nanopore technology and for the bioinformatic processing of the resulting data.
• Define a coherent set of molecular biology techniques necessary for the experimental realization of the scientific project, taking into account the constraints of the associated computer scientists/bioinformaticians
• To conceive the development and to lead in specialist, the realization of the production of the DNA molecules dedicated to the storage of information then to the preparation of the DNA banks for sequencing. Carry out the sequencing and their primary analysis in bioinformatics
• Advise, within the framework of this project, the non-biological partners in order to define the biological constraints applying to the project, the technical options; evaluate and validate the choices in consultation
• Disseminate and promote the results and technological achievements
• Train, internally and externally, any trainees in the principles and implementation of biological experimentation techniques
• Ensure a scientific and technological watch in the field of DNA information storage technologies
• Manage the technical and financial means allocated to the experimentation activities
- Molecular biology of nucleic acids, cloning, high throughput sequencing, banking and sequencing
- Health and safety regulations
- Computer knowledge in high throughput sequencing data analysis is required
- English language: B2 to C1 (Common European Framework of Reference for Languages)
- Design experimental devices
- Develop scientific and technological expertise in the production and analysis of DNA sequences for information storage
- Use software specific to the activity
- Write scientific documents
- Engineering school, master
Field of training
- molecular biology of nucleic acids,
IRISA (Institut de Recherche en Informatique et Systèmes Aléatoires) is today one of the largest French research laboratories (over 850 people) in the field of computer science and new information technologies. Structured in seven scientific departments, the laboratory constitutes a pole of research excellence with scientific priorities such as: bioinformatics, system security, new software architectures, virtual reality, mass data analysis and artificial intelligence.
The candidate will be mainly attached to the GenScale team, IRISA, Beaulieu, Rennes (D. Lavenier), but part of the mission will take place at the IGDR, Villejean, Rennes, in the GED team (Y. Audic)
GenScale is a research team in bioinformatics. Its main objective is to develop methods, tools and scalable software for genomic data processing. The research is motivated by the rapid development of next-generation sequencing (NGS) and third-generation sequencing (TGS) technologies which pose very challenging problems in terms of both bioinformatics and computer science.
The "Gene expression and development" (GED) team studies post-transcriptional regulations, using mainly the amphibian xenopus, cells in culture and the mouse as models. This research has a strong impact on the understanding of certain human pathologies.
For these two teams, the dnarXiv project represents a new research axis.
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