Missions

The research subgroup titled “Tumor Heterogeneity in Liver Cancers” focuses on the mechanisms of hepatic carcinogenesis. Hepatocellular carcinoma (HCC) remains the third leading cause of cancer-related death. Most patients with HCC are diagnosed at an advanced stage, making them ineligible for curative surgical interventions, and therapeutic options remain limited. One of our research projects aims to characterize the oncogenic role of an amplified receptor in HCC. Our objective is to decipher this oncogenic mechanism in hepatocarcinogenesis and to enhance the antitumor activity of a therapeutic antibody developed by our collaborators.

The selected candidate will be responsible for driving this project forward. They will be able to carry out experiments independently with support from team members, analyze and interpret their results, and present them to diverse audiences. Initial 14-month contract, with the possibility of extension.

Activités

- Performing experiments and analyzing data, using approaches such as:
- Cell biology (e.g., genetic manipulations, flow cytometry, microscopy, etc.)
- Molecular biology (e.g., transcriptomic approaches, cloning, etc.)
- Biochemistry (e.g., Western blotting, pull-downs, immunoprecipitation, etc.)
-histology
- in vivo experiments
The successful candidate will also be expected to:
- Develop experimental protocols and share them with other team members
- Demonstrate an ability to work collaboratively and interact with bioinformaticians, platform operators, and researchers
- Keep up to date with scientific and technological advances in their field
The selected candidate will work in close collaboration with the extensive network of core facilities available within the Montpellier scientific community (transcriptomics, proteomics, metabolomics, imaging, etc.).
They will also be involved in disseminating the results of the projects.

Compétences

The highly motivated candidate will hold at least a PhD in molecular biology, cell biology, or a related discipline.
In addition, they must be able to summarize, write, and present their results in English.
The candidate should be capable of working independently on their specific research projects, while also collaborating with other team members to integrate their findings into physiopathological contexts.

Contexte de travail

The Institute of Molecular Genetics of Montpellier (IGMM) is a joint research unit of the CNRS and the University of Montpellier, with a staff of around 200 people distributed among 18 research groups, 9 shared services (5 of which are jointly managed with other units on the CNRS campus), and 9 technological and scientific platforms.
IGMM is a multidisciplinary institute whose work has an international impact, both fundamental and applied, in molecular and cell biology (www.igmm.cnrs.fr
).
The successful applicant will work under the supervision of Damien Grégoire within the research subgroup entitled “Tumor Heterogeneity in Liver Cancer”, also led by Damien Grégoire, and composed of 8 to 10 members.
This subgroup belongs to the research group “Inflammation and Cancer”, which comprises 20 members in total and is headed by Michael Hahne.
The project benefits from the outstanding scientific environment of the Biocampus and its technological platforms (proteomics, sequencing, imaging, www.biocampus.cnrs.fr
).

Contraintes et risques

The position may involve work in biosafety containment areas.
Work on shift/off-hours schedules may be required.