Missions

A position for a researcher at the Institut Lumière Matière in Lyon, France (iLM -Université Claude Bernard Lyon 1, CNRS) as part of the ANR MOONSTONE project. The MOONSTONE project aims to develop an innovative portable sepsis diagnostic sepsis diagnosis to enable effective antibiotic treatment and combat to combat antibiotic overuse. The success of the platform will depend on the development of chemically functionalized porous silicon surfaces surfaces and the development of time-of-flight mass spectrometry in the mass spectrometry in the high mass range using IR desorption and an electrospray electrospray ionization source.

The researcher hired at iLM-CNRS will be responsible for be responsible for leveraging our local expertise in charge detection mass spectrometry charge detection mass spectrometry (CDMS) and ionization source development (laser/electrospray desorption). He/she will be responsible for the development of CDMS spectrometry and its coupling to a new ionization source using IR desorption IR desorption and an electrospray ionization source.

Activités

The candidate will be in charge of implementing a new methodology in order to :
- Optimize conditions for gas-phase introduction and ionization of large biomolecules.
- Couple the charge detection mass spectrometer with an ionization source using IR desorption and an electrospray ionization source.
- Ensure data processing and scientific dissemination of results (drafting of articles in English, conferences).

Compétences

The candidate must hold a PhD in physical chemistry or chemistry (bio/analytical). He/she must have experience in laser optics and in mass spectrometry (MALDI-MS and ESI-MS). Experience in MS instrumentation is a strong asset. The candidate must be comfortable handling biological samples (large proteins and assemblies): purification, storage and have a critical eye for assessing the structural integrity of systems.

Contexte de travail

The Institute for Light and Matter (Institut Lumière Matière - iLM) is a joint CNRS-University of Lyon 1 research unit located on the Lyon Tech La Doua campus.
With approximately 300 employees, including a hundred doctoral students and post-docs, the iLM is a major player in physics and chemistry research in the Auvergne Rhône Alpes region, internationally recognized for the excellence of its research.
The continuum between fundamental research, responses to major societal challenges and innovation is at the heart of the unit's approach. The entire staff is committed to promoting excellence and ethical and responsible research.
Its scientists explore six major thematic fields:
Materials, Energy, Photonics
Soft Matter
Nanosciences
Optics and Ultrafast Dynamics
Theory and Modeling
Living Matter, Health, Environment.
The ILMTech technology platform, a gateway to innovation, offers cutting-edge instruments and expertise to academic and socio-economic players.
The results of the research lead to the publication of about 250 articles per year in international peer-reviewed journals, half of which are with international collaborators, and 6 patents per year.
8 start-ups and a Labcom have emerged from the iLM and position it as a major player in deep technology.
10 European projects, 50 ANR projects (French National Research Agency), 30 industrial contracts are currently open with a contractual budget of 4 M€ for a consolidated budget of over 20 M€.
140 trainees and 50 international visitors are welcomed each year, making iLM a multicultural place with more than 30 nationalities present.

Contraintes et risques

laser safety and aerosol safety.