Informations générales
Intitulé de l'offre : Study of the morphological impact of nanoparticles used as probes of the brain's extracellular space by super-resolution optical microscopy. (M/F) (H/F)
Référence : UMR5298-LAUCOG-013
Nombre de Postes : 1
Lieu de travail : TALENCE
Date de publication : lundi 6 octobre 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 18 mois
Date d'embauche prévue : 1 janvier 2026
Quotité de travail : Complet
Rémunération : 2 991€ to 3 417€ gross monthly depending on past experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : Indifférent
Section(s) CN : 05 - Matière condensée : organisation et dynamique
Missions
Single particle tracking methods enable the investigation of molecular diffusion properties in complex environments. Our group has recently demonstrated that, through imaging of individual nanotubes, we have a unique opportunity to elucidate—at the nanoscale—the complexity of molecular diffusion within the brain's extracellular space. This is a key cerebral compartment for physiological tasks, local and long-distance molecular communication between brain cells, and the delivery of therapeutic molecules.
In this context, the mission of the recruited postdoctoral researcher will be to study the impact of nanoparticle morphologies used in our high-resolution/super-resolution optical microscopy approaches (single particle tracking). A key challenge will be to reveal the interplay between the nanostructured organization of the brain (studies on live mouse brain slices) and the morphology of the objects/molecules circulating within it.
Activités
Optical engineering – laser alignment
Optical microscopy – design and setup of experiments
Microscopy sample preparation
Instrumentation/computer interfacing
Computer programming (Python, MATLAB) – data analysis – modeling
Writing reports and articles
Scientific literature review
Compétences
Proven expertise in:
Optical instrumentation
Nanoscience
Photophysics of carbon nanotubes
Image analysis and simulations
Strong interest in interdisciplinary research
Contexte de travail
This multidisciplinary project will take place at the University of Bordeaux campus within the framework of an ERC Synergy Award, in the laboratory of Laurent Cognet (Laboratoire photonique, numérique, nanosciences, https://www.lp2n.institutoptique.fr/) in tight collaboration with Dr. Laurent Groc (Interdisciplinary Institute for Neuroscience ; https://www.iins.u-bordeaux.fr/) and Dr. Erwan Bézard (Institute of Neurodegenerative Diseases, https://www.imn.u-bordeaux.fr/), The LP2N laboratory is recognized worldwide for its research in the field of optics.