Informations générales
Intitulé de l'offre : Neuroscience Researcher 'Study of the mechanisms of mechanotransduction mediated by the axonal cytoskeleton' M/F (H/F)
Référence : UMR5297-MELDES0-293
Nombre de Postes : 1
Lieu de travail : BORDEAUX
Date de publication : mercredi 12 novembre 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 4 mois
Date d'embauche prévue : 1 janvier 2026
Quotité de travail : Complet
Rémunération : Between €2,991.58 and €3,417.33 gross monthly depending on experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : Indifférent
Section(s) CN : 25 - Neurobiologie moléculaire et cellulaire, neurophysiologie
Missions
Analysis of mechanotransduction mediated by the periodic axonal cytoskeleton: Application of different treatments on neurons (drugs that disrupt different transduction pathways, protein depletion) and analysis of the impact on the nanoscopic organisation of the axonal cytoskeleton before and after mechanical stimulation, mainly using super-resolution imaging.
Activités
Immunolabelling and viral infection on neurons. STORM and DNA PAINT super-resolution microscopy and associated image analysis. Preparation of cell stretching devices compatible with super-resolution microscopy.
Compétences
Work on hippocampal neuron culture. Handling of non-replicative lentiviruses. Knowledge of neuronal cell biology, particularly cytoskeletal proteins and mechanobiological processes. Proficiency in techniques and analyses associated with microscopy, particularly super-resolution microscopy (STORM and DNA PAINT). In-depth knowledge of Matlab software.
Contexte de travail
Created on 1 January 2011, the Interdisciplinary Institute for Neuroscience (IINS) is a joint research unit affiliated with the CNRS and the University of Bordeaux. With 170 staff members divided into 12 teams, IINS combines multidisciplinary expertise to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As part of Bordeaux Neurocampus, IINS is one of the major players in the neuroscience community in Aquitaine.
Contraintes et risques
Possibility of working staggered hours