General information
Offer title : Neuroscience Researcher 'Study of the mechanisms of mechanotransduction mediated by the axonal cytoskeleton' M/F (H/F)
Reference : UMR5297-MELDES0-293
Number of position : 1
Workplace : BORDEAUX
Date of publication : 12 November 2025
Type of Contract : Researcher in FTC
Contract Period : 4 months
Expected date of employment : 1 January 2026
Proportion of work : Full Time
Remuneration : Between €2,991.58 and €3,417.33 gross monthly depending on experience
Desired level of education : Doctorate
Experience required : Indifferent
Section(s) CN : 25 - Molecular and cellular neurobiology, neurophysiology
Missions
Analysis of mechanotransduction mediated by the periodic axonal cytoskeleton: Application of different treatments on neurons (drugs that disrupt different transduction pathways, protein depletion) and analysis of the impact on the nanoscopic organisation of the axonal cytoskeleton before and after mechanical stimulation, mainly using super-resolution imaging.
Activities
Immunolabelling and viral infection on neurons. STORM and DNA PAINT super-resolution microscopy and associated image analysis. Preparation of cell stretching devices compatible with super-resolution microscopy.
Skills
Work on hippocampal neuron culture. Handling of non-replicative lentiviruses. Knowledge of neuronal cell biology, particularly cytoskeletal proteins and mechanobiological processes. Proficiency in techniques and analyses associated with microscopy, particularly super-resolution microscopy (STORM and DNA PAINT). In-depth knowledge of Matlab software.
Work Context
Created on 1 January 2011, the Interdisciplinary Institute for Neuroscience (IINS) is a joint research unit affiliated with the CNRS and the University of Bordeaux. With 170 staff members divided into 12 teams, IINS combines multidisciplinary expertise to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As part of Bordeaux Neurocampus, IINS is one of the major players in the neuroscience community in Aquitaine.
Constraints and risks
Possibility of working staggered hours