Informations générales
Intitulé de l'offre : Neuroscience researcher 'Development of new approaches to the physico-chemical coupling of nanoparticles in order to complete the study of the mobility of molecules in the extracellular space' M/F (H/F)
Référence : UMR5297-MELDES0-275
Nombre de Postes : 1
Lieu de travail : BORDEAUX
Date de publication : mercredi 2 juillet 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 18 mois
Date d'embauche prévue : 1 septembre 2025
Quotité de travail : Complet
Rémunération : From €2991.58 to €3417.33 gross per month depending on experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : Indifférent
Section(s) CN : 25 - Neurobiologie moléculaire et cellulaire, neurophysiologie
Missions
Development of new approaches to the physico-chemical coupling of nanoparticles in order to complete the study of the mobility of molecules in the extracellular space (ECS). Modulation of the density of the extracellular matrix using viral tools in order to demonstrate the regional specificity of molecule diffusion in the hippocampus, and analysis of the impact of this modification of the ECS using state-of-the-art microscopy techniques. Application to translational projects, using patients' pathogenic autoantibodies as target molecules.
Responsible for the team's Spinning disk imaging setup with over 15 weekly users and supervising and training students on single particle tracking technology.
Activités
The candidate will implement super-resolution imaging approaches in in vitro and ex vivo models. He will develop new approaches for coupling nanoparticles with different antibodies in order to facilitate particle tracking in more integrated models. Finally, it acts by modifying the density of the extracellular matrix using recombinant viral vectors.
Compétences
Chemistry, Fluorescence Imaging, Cell Biology, Vectorology
Contexte de travail
Created on 1 January 2011, the Institut interdisciplinaire de neurosciences (IINS) is a joint research unit attached to the CNRS and the University of Bordeaux. With 170 staff in 12 teams, IINS combines multidisciplinary skills to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As part of Bordeaux Neurocampus, IINS is one of the major players in the neuroscience community in Aquitaine.
Contraintes et risques
Possibility of working shifts