Missions

Study of synaptic function using electrophysiological, molecular and imaging approaches

Activities

We are looking to recruit a post-doc with an interest in cellular neuroscience and strong expertise in slice or in vivo imaging and/or physiology, including spine morpho-dynamics, synaptic plasticity, receptor trafficking and nanoscale organization, to join a dynamic environment and exciting project combining high-resolution imaging, biosensors, slice imaging and electrophysiology to study novel aspects of synaptic plasticity. We have developed unique tools to monitor and modify the organization of AMPA receptors at the nanoscale and the trafficking of single molecules in vivo and in brain slices. The candidate will apply these to the study of synaptic function using electrophysiological, molecular and imaging approaches. He/she will use these tools to analyze the role of AMPAR trafficking in synaptic plasticity and information processing through to network activity in the normal and diseased brain.
Overall, this project will shed new light on the molecular mechanism of synaptic plasticity and will be linked to behavioral studies of cognitive functions using the same tools.

Skills

We are looking for a highly motivated, proven individual with expertise in cross-sectional or in vivo imaging, if possible immediately after their PhD, and in any case no more than four years after their PhD.

Work Context

Created on January 1, 2011, the Institut interdisciplinaire de neurosciences (IINS) is a joint research unit attached to the CNRS and the University of Bordeaux. With 170 staff in 14 teams, IINS combines multidisciplinary skills to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As part of Bordeaux Neurocampus, IINS is a major player in the neuroscience community in Aquitaine.

Constraints and risks

Possibility of working shifts