Missions

The postdoctoral position is for a period of one year and the research topic focuses on the study of macropinocytosis and the metabolic determinants of stress adaptation in glioblastoma stem cells (in vitro and in vivo experiments).

Activities

In vitro and in vivo analysis of metabolism and the effects of stress on different cell models derived from patients with glioblastoma and animal experimentation (survival, angiogenesis, invasion, etc.).

Skills

The candidate must hold a PhD in cellular and molecular biology with a relevant publication record in international journals in the field of research being explored. He/she must demonstrate strong motivation, excellent teamwork skills, creativity, and independence of mind, and must have solid practical and technical experience (in vitro and in vivo). The candidate must have worked in the field of metabolic adaptation of cancer cells to stress. Experience in the field of glioblastoma or oncology is recommended. An excellent level of English (written/spoken) is essential and required.

Work Context

Access to nutrients is vital for all cells, whether tumorous or healthy. Numerous studies have shown that tumor cells are capable of reprogramming their metabolism in order to survive the various stresses present in the tumor microenvironment. Thus, the metabolic pressures imposed by this microenvironment create certain metabolic dependencies and vulnerabilities in tumor cells that can be exploited therapeutically. The overall objective of this project is to study and understand the cellular and molecular mechanisms implemented by tumor cells to better tolerate and survive. From a fundamental perspective, this project seeks to identify the molecular mechanisms governing the adaptation of GBM tumor cells to different types of stress. From a translational perspective, this project will reveal new biomarkers and new therapeutic targets for the treatment of GBMs.

The Lyon Cancer Research Center (CRCL) is an internationally renowned center dedicated to innovative research in oncology. Comprising more than 600 researchers and clinicians, the CRCL is dedicated to understanding the mechanisms of cancer and developing new therapeutic strategies.
You will work in an international scientific environment dedicated to cancer research, thanks to the presence of 24 research teams and 12 technology platforms on site.