Missions

The successful candidate will join the “Phagocyte Architecture and Dynamics” team at IPBS. He/she will develop a research project aimed at understanding the functioning of macrophage podosomes and will participate in various team projects. This study will be carried out under the supervision of Renaud Poincloux.

Activités

The IR will be in charge of developing his/her project and will participate in various team projects. He/she will be responsible for the design, implementation and interpretation of experiments. To this end, he/she will work independently, but also with other team members and collaborators for the needs of the project. He/she will participate in the dissemination and valorization of results, and will monitor the literature in the field.

Compétences

Experience in cell biology, biophysics and/or imaging is expected. We are looking for a candidate who is autonomous, rigorous, dynamic, motivated and persevering. The candidate must demonstrate organizational skills, meticulousness and a strong sense of ethics.

Contexte de travail

The project will be developed at the IPBS, a joint research unit of the CNRS and Paul Sabatier University (University of Toulouse). The primary objective of the IPBS is to identify, characterize and exploit new therapeutic targets in the fields of cancer, infection and inflammation. The postdoctoral fellow will join the team led by Renaud Poincloux and Christel Vérollet, which studies the interactions between phagocytes and their environment, in both physiological and pathological contexts.

7 recent publications by the team:
Verdys P et al. (2024) Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics EMBO J
Mascarau M et al. (2023) Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells. J Cell Biol
Portes M et al. (2022) Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts. Elife
Jasnin M et al. (2022) Elasticity of dense actin networks produces nanonewton protrusive forces. Nat Commun
Dupont M et al. (2020) Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. Elife
Souriant S et al. (2019) Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages. Cell Rep
Raynaud-Messina B et al. (2018) The bone degradation machinery of osteoclasts: a novel HIV-1 target that contributes to bone loss. Proc Natl Acad Sci USA