Missions

The researcher will contribute to the development of a method for immobilizing enzymes for applications mainly in the agri-food industry, particularly using enzymes isolated from extremophile organisms.

Activités

- Crystallize proteins. Develop batch crystallization protocols in particular
- Apply and improve an immobilization protocol
- Measure enzyme activity under various conditions
- Purify proteins
- Characterize proteins using biophysical approaches
- Format weekly results in our electronic lab notebook
- Present results monthly within the laboratory and/or institute
- Be proactive in developing and improving experiments
- Write scientific results in English for publication of the work carried out
- Participate in the Institute's scientific events

Compétences

- Expertise in biochemistry
- Proficiency in enzyme activity measurement techniques
- Proficiency in protein crystallization
- Proficiency in protein immobilization techniques
- In-depth knowledge of protein crystallography
- English (written/spoken) minimum level B2 (according to the Common European Framework of Reference for Languages)
- Knowledge of and compliance with current health and safety regulations in laboratories.
- High degree of autonomy
- Scientific curiosity
- Good interpersonal skills and ability to integrate and adapt to the team
- Strong organizational skills and rigor
- Communication skills (written and oral) and ability to report on your work

Contexte de travail

Located in Grenoble's Science Park (ESRF/ILL/EMBL/IBS), the Institute of Structural Biology (IBS) is a major national and international player in the field of integrated structural biology. As a research center, technical platform, and scientific training site, the IBS is dedicated to advancing research in structural biology, a field that is crucial to understanding fundamental biological mechanisms. It is supported by 12 state-of-the-art platforms.
As a joint research unit (CEA-CNRS-UGA), the IBS is composed of 20 research groups, each offering a multidisciplinary approach at the frontiers of biology, physics, and chemistry, in line with three areas of research. Nearly 320 people work there, including researchers, doctoral students, engineers, and technicians, in a multicultural and international environment.
The successful candidate will join the ELMA group, which focuses on both the molecular mechanisms that enable organisms to evolve in extreme conditions and the mechanisms that maintain proteome integrity (https://www.ibs.fr/ en/research/dynamic-assembly-and-reactivity/extremophiles-and-large-molecular-assemblies-group-b-franzetti/). The ELMA group is also developing new applications in biotechnology, particularly the modification of protein hydrolysates.

Contraintes et risques

None.
Research will be conducted in either French or English, but non-French-speaking candidates are expected to make an effort to learn the basics of French in order to facilitate communication and integration into the laboratory.