General information
Offer title : Post-doctoral researcher in biology (M/F) (H/F)
Reference : UMR3348-SOPBEI-001
Number of position : 1
Workplace : ORSAY
Date of publication : 07 May 2024
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 October 2024
Proportion of work : Full time
Remuneration : Between €2,993 and €4,204 depending on experience
Desired level of education : Niveau 8 - (Doctorat)
Experience required : 1 to 4 years
Section(s) CN : Cellular biology, development, evolution-development, reproduction
Missions
As part of a European Research Council (ERC) project, the CNRS is recruiting a full-time post-doctoral researcher in the "Regulation of Microtubule Dynamics by Tubulin Code" team, led by Carsten JANKE, Institut Curie, CNRS UMR3348, to investigate the molecular effects of tubulin code and their impact on functions at the organismal level. The focus of this post-doc will be to study the pathological effects of hyper-polyglutamylation in neurons and in vitro.
Activities
Specific activities include carrying out experiments and analysing data, in particular using :
- Molecular biology (cloning, Q-PCR, etc)
- Cell biology (primary culture of neurons, transduction with lentiviruses, marking of endogenous proteins with CRISPR/Cas9, etc)
- Microscopy (live cell imaging, immunolabelling, expansion microscopy, superresolution microscopy, etc)
- Analysis of microscopic images, mounting
- Biochemistry (protein analysis by western blots, proximity ligation tests, etc)
- Animal experimentation (planning mouse crosses for the project, mouse dissection, genotyping, analysis of animals for immunohistochemistry, etc)
The candidate will interact closely with the members of his/her team and the collaborating teams in the network for this ERC project, as well as with the platforms available at the Institut Curie Research Centre.
The candidate will also be involved in the dissemination of project results, through publications, oral presentations and presentations to the general public.
Skills
The highly motivated candidate must hold a PhD in cell biology, immunology, biochemistry, molecular biology or a related discipline. Knowledge of animal experimentation (mice), cell biology and microscopy is required, as well as skills in image analysis, molecular biology and biochemistry.
The candidate must be able to work independently to develop innovative ideas, but also to collaborate with other members of the laboratory and the network of teams involved in the ERC, to promote interdisciplinarity. The candidate will have excellent communication skills and a good command of English.
Work Context
The Controlling microtubule dynamics and function with the tubulin code
team is based at the Institut Curie Research Centre in Orsay (91), within UMR3348 CNRS.
Constraints and risks
Experiments in confined areas are necessary.