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Portail > Offres > Offre FR550-BRUMIR-014 - Post-doctorat "Approches multi-échelles pour étudier le paysage conformationnel des assemblages de protéines flexibles : Déchiffrer le complexe de la NADPH oxydase" (H/F)

Post-doc "Multiscale approaches to investigate the conformational landscape of flexible protein assemblies: Deciphering the NADPH oxidase complex" (M/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : vendredi 29 octobre 2021

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General information

Reference : FR550-BRUMIR-014
Workplace : PARIS 05
Date of publication : Friday, September 17, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2022
Proportion of work : Full time
Remuneration : Gross salary will vary with candidate's experience starting at 3106€/month before taxes (around 2500€ after taxes) for candidate with less than 2 years post-doctoral experience. See the official CNRS salary table for researcher at http://labexdynamo.ibpc.fr/fp-dynamo-paris/
Desired level of education : PhD
Experience required : Indifferent

Missions

Attention: You must not have resided or carried out your main activity (e.g. work or studies) in France for more than 12 months in the 3 years prior to the recruitment date.
You have research experience in the field relevant to the call.

This project focuses on the phagocyte NAPDH oxidase (NOX) complex whose flexibility is central for their activity.
This will require taking in account the various conformations potentially adopted by the unstructured regions. This involves the elaboration of a new computational strategy adapted to the modeling of proteins composed of structured domains separated by flexible segments.
PI: S. Sacquin-Mara (sophie.sacquin-mora@ibpc.fr), co-PI: A.Taly (taly@ibpc.fr); UPR9080

Activities

• Using Molecular Dynamics (MD) simulations to generate relevant conformational ensembles for the flexible linkers connecting the complex structured domains. This will require the use of state of the art force fields, that are suitable for modeling both structured and disordered protein regions.

• Investigating the interactions between the structured domains with an integrative docking
strategy (using both coarse-grain and all-atom representation levels), that will take into account structural constraints produced by the MD simulations on the linkers and experimental data from our experimental partners.

Skills

-The candidate should hold a PhD in Computational chemistry, physics or
Bioinformatics, with a strong background in modeling of biomolecular systems.
- Experience in classic modeling tools such as Molecular Dynamics or Docking is expected.
- Excellent communication skills in English, both verbal and written, are required.

Work Context

The Institute of Physical and Chemical Biology, in association with the CNRS, offers an exceptional environment for early career scientists, with a dynamic international exposure animated by regular seminars and meetings. The Laboratory of Theoretical Biochemistry (LBT) is internationally recognized for the development and application of computational methodologies to solve biologically relevant problems. Its members are active in the fields of docking, atomic and coarse-grained simulations, addressing problems such as protein/protein and protein/DNA interactions, membrane protein dynamics and function, protein folding and aggregation.

The COFUND FP-DYNAMO-PARIS programme offers a unique interdisciplinary environment and a fundamental research initiative in the centre of Paris to train the scientists of tomorrow in the field of physico-chemical biology. The goal of the research programme is to integrate knowledge on gene expression, structural and membrane biology, and bioenergetics in bacteria, chloroplasts and mitochondria in the general context of improving our understanding the biogenesis of energy-transducing membranes. These studies will involve cutting-edge technologies including structural biology (NMR, X-ray crystallography and CryoEM), RNA sequencing, mass-spectrometry, synthetic biology, microfluidics, computational modelling and visualization. Post-doctoral fellows will have the opportunity of developing their research projects in a dynamic scientific environment covering three main research themes: i) RNA biology from bacteria to chloroplasts, ii) Membrane system dynamics and iii) computational modelling of molecular assemblies. They will benefit from the supervision of internationally-recognised experts in their fields, a world-wide network of renowned institutions, cutting-edge research infrastructure and state-of-the-art technical know-how that will allow them to hone their scientific skills, make themselves known and increase their competitiveness on the labour market. Specific training will be proposed to ERs through attendance of the EMBO course on “Laboratory Leadership for Postdocs” included in a retreat in Padua, and involvement in dedicated complementary soft skill training events.

Constraints and risks

The contract must start between 1 January 2022 and 31 May.

Additional Information

The application should be written in English and uploaded at https://emploi.cnrs.fr/. It should include a detailed CV, a minimum of two letters of reference, a letter of motivation describing your short and long term career objectives, and a signed declaration stating that you are in compliance with the mobility rule which stipulates that you have not resided or carried out your main activity (work or studies) in France for more than 12 months during the three years preceding the date of recruitment. In addition, the complete file must also be sent to Bruno MIROUX & Magdalena TORTYNA, respectively director and manager of the project at the following email address DYNAMOcofund@ibpc.fr (Tel: 33 1 58 41 50 64). See details on the website http://labexdynamo.ibpc.fr/fp-dynamo-paris/
The position is intended as an initial step in a research career, and the assessment of the applicants will primarily be based on their research qualifications and their potential as researchers with skills that complement and strengthen on-going research within the partner institutions.

Step 1. The applications of each eligible candidate will be evaluated by independent international experts within the relevant research theme. Eligible applicants will be evaluated based on merits, motivation for the program, academic excellence and personal qualifications such as collaborative and communication skills.

Step 2. A maximum of three candidates will be retained for a video interview with the independent experts for each open position (Nov 2021). After the interview, candidates on the short list will be invited to a conference call with the project supervisor and a DYNAMO board member to define the general scope of the project, the training and the research environment. Candidates will be asked to draft a 3-page project proposal, bringing their own original ideas and will be given 2 weeks to submit it.

Step 3. Each project proposal will be evaluated by one of the independent experts and the DYNAMO board member who evaluated the candidate in the previous steps. The final selection will be made based on the scores obtained at steps 1, 2 and 3. The minimum score must be above 20/40. Top candidate will be offered the postdoc position with a starting date from January 1- May 31, 2022.

The CNRS (Centre National de la Recherche Scientifique) is an equal opportunity employer. Furthermore, FP-DYNAMO-PARIS is committed to promoting the role of women in science and thus explicitly encourages women to apply

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