Informations générales
Intitulé de l'offre : M/F M2 student internship in physical-chemistry - Exploring photophysical and photochemical properties of novel heptamethine cyanine dyes for photothernostics (H/F)
Référence : UMR7053-YANBER-015
Lieu de travail : VANDOEUVRE LES NANCY
Pays : France
Date de publication : vendredi 31 octobre 2025
Type de contrat : Convention de stage
Durée du contrat : 6 mois
Date d'embauche prévue : 5 janvier 2026
Quotité de travail : Complet
Niveau de diplôme préparé : BAC+5
BAP : A - Sciences du vivant, de la terre et de l'environnement
Description du poste
Project context: Cyanine dyes, particularly near-infrared absorbing heptamethine cyanines (Cy7), possess outstanding photophysical and photochemical properties, making them highly attractive for phototheranostic applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). However, their limited photostability—manifested as rapid photobleaching—remains a major obstacle. Our research team focuses on the development of novel Cy7 derivatives and Cy7 aggregates with enhanced photostability and improved phototheranostic performances. To guide rational molecular design, a deeper understanding of the interplay between chemical structure, excited-state dynamics, and therapeutic efficacy is essential.
Mission: The recruited person will be in charge of the characterization of photophysical and photochemical properties of new Cy7 derivatives using both steady-state and time-resolved absorption and fluorescence spectroscopic techniques. The candidate will also contribute to the development and optimization of dedicated experimental setups tailored to specific phototheranostic parameters (photobleaching resistance, reactive oxygen species (ROS) generation, and photothermal conversion efficiency).
Description de l'employeur
The Laboratoire Lorrain de Chimie Moléculaire (L2CM), located in Vandoeuvre-les-Nancy, France, is a young laboratory dedicated to molecular chemistry and its applications. It brings together 70 members including synthetic chemists, physical chemists, nanomaterials specialists and biologists.
Descriptif du profil recherché
You should hold a Master 1 degree in physical chemistry or related field, with at least one practical experience in the lab. Interest/experience in spectroscopy studies of dyes would be appreciated. Autonomy, reliability, and organization skills are highly required. The project offers an opportunity for a highly motivated student to develop a broad range of competencies within research areas that hold significant academic.
Conditions particulières d'exercice
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Langues
French/English
Informations complémentaires
Applications should be sent to Dr. Yann Bernhard (yann.bernhard@univ-lorraine.fr). It should include a detailed CV, a cover letter highlighting how you meet the criteria, and your M1 (or equivalent) grades reports.
The starting date is flexible, between January and March 2026, for a period extending until July or August 2026.
Commentaires
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