Description du sujet de thèse

The PhD student (M/F) will work on the project “Aedes aegypti metabolism as regulator of disease tolerance and vector
competence.”, with the aim of studying the link between mosquito energy metabolism during arboviral infection. It will determine whether we can explore the intermediary metabolism of the mosquito to reduce its vector competence towards Zika and Dengue virus.

Contexte de travail

The PhD student (M/F) will join the 'Mosquito Metabolism and Vector Competence' team of the M3i unit UPR9022 at IBMC, “Models of innate immunity in insects” at the Institute of Molecular and Cellular Biology (IBMC). Our team studies the molecular basis underlying interactions between mosquitoes and the pathogens they transmit, and on the basis of these results, designs new strategies to control disease transmission. The PhD student (M/F) will benefit from interactions with students and researchers working on different insect models (Drosophila and mosquitoes) but also from dynamic, scientific and technical, as well as multidisciplinary collaborations with other units housed in the institute This project will be supervised by Dr José Henrique M. Oliveira. M3i - IBMC (cnrs.fr)
M3i — IBMC (cnrs.fr)
The salary will be 2300€ gross (and not 2200€)

Contraintes et risques

Usual constraints linked to biology laboratory work and to the follow-up of experiments and maintenance of mosquito lines.
Working with mice.
Working with pathogens in a level 3 containment laboratory.
Mosquito on-call duty on weekends or public holidays (3 hours once every 3-4 months).