PhD in Bioinorganic chemistry, metallopeptides/proteins synthesis and engineering (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de chimie de coordination
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31077 TOULOUSE
Contract Duration
36 months
Date of Hire
01/11/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 24 August 2026 23:59
Job Description
Thesis Subject
Lanthanides (Ln) cover ubiquitous and crucial roles in modern technology, including for green energy transition, optics, medical diagnostics and radiation therapy. In this context, a recently discovered (2018) Ln binding protein, Lanmodulin (LanM), is of interest for emerging applications in biometallurgy and bioimaging due to its outstanding Ln coordination properties (e.g. high affinity and high selectivity vs Ca2+ and d-block metals). However, LanM applications are still hampered by low kinetic inertness and low intra-Ln selectivity. In order to overcome these limitations and unlock LanM full potential for (bio)technological applications, the OPTIMAL project aims to develop engineered LanM variants with optimised coordination properties. To this end, unprecedented chemical modifications, notably non-native amino acids (nnAAs) for Ln coordination as well as for advanced characterization (e.g. by 19F-NMR), will be introduced in LanM via a semi-synthetic approach based on native chemical ligation (NCL). This method will allow the modification of a protein fragment with nnAAs and its ligation with the unmodified complementary fragment, which will be recombinantly expressed. As a result, OPTIMAL will deliver artificial Ln-binding sites with high affinity and intra-Ln selectivity, boosting the potential of LanM and Ln-proteins for relevant societal applications. In addition, OPTIMAL will also broaden the fundamental knowledge on the coordination properties of Ln-binding proteins, which is currently limited, significantly contributing to this blooming research field.
Your Work Environment
The work will be carried out at the Laboratory of Coordination Chemistry of the CNRS
(UPR 8241) in the "Alzheimer, Amyloids & Bioinorganic Chemistry" team under the supervision of Dr. Enrico Falcone and Dr. Christelle Hureau (team leader).
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UPR8241-ENRFAL-001 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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