En poursuivant votre navigation sur ce site, vous acceptez le dépôt de cookies dans votre navigateur. (En savoir plus)

PhD student in physical chemistry of amyloid peptides (M/W)

This offer is available in the following languages:
- Français-- Anglais

Date Limite Candidature : lundi 5 juin 2023

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler. Les informations de votre profil complètent celles associées à chaque candidature. Afin d’augmenter votre visibilité sur notre Portail Emploi et ainsi permettre aux recruteurs de consulter votre profil candidat, vous avez la possibilité de déposer votre CV dans notre CVThèque en un clic !

Informations générales

Intitulé de l'offre : PhD student in physical chemistry of amyloid peptides (M/W) (H/F)
Référence : UPR8241-CHRHUR-008
Nombre de Postes : 1
Lieu de travail : TOULOUSE
Date de publication : lundi 15 mai 2023
Type de contrat : CDD Doctorant/Contrat doctoral
Durée du contrat : 36 mois
Date de début de la thèse : 1 septembre 2023
Quotité de travail : Temps complet
Rémunération : 2 135,00 € gross monthly
Section(s) CN : Chemistry of and for life: design and properties of molecules of biological interest

Description du sujet de thèse

Peptide self-assembly is a feature of increasingly common diseases, including type 2 diabetes (T2D) and Alzheimer's disease (AD). These diseases involve the formation of amyloid fibres, either from amylin peptide (T2D) or from Aβ (AD). The imaging detection of these fibres is important both for diagnosis and for a better understanding of the molecular mechanisms of these diseases. Despite the large number of imaging probes described for the detection of amyloid fibres, none has so far shown selectivity for amylin-type amyloids over Aβ-type amyloids. As more and more evidence suggests a link between T2D and AD, the selective detection of amylin and Aβ amyloids becomes important. It is within this framework that the research proposed for this doctoral project takes place.
Imaging probes, bi-functional compounds containing a fibre targeting unit and a unit based on a Ln complex for MRI (magnetic resonance imaging) will be synthesised and characterised by our collaborators (CBM, Orléans).

In the Laboratoire de Chimie de Coordination (LCC), and within the ALAMBIC team, the subject will be articulated around two axes:
(i) Study of the self-assembly process of amylin and Aβ peptides, and their co-assembly.
(ii) Study of the interaction of probes with amyloids, and evaluation of the selectivity for amylin or Aβ fibres.

The technical and scientific environment of the laboratory and the host team is of high quality. The PhD student will be trained in advanced spectroscopic techniques such as NMR (paramagnetic), UV-Vis and circular dichroism, fluorescence and imaging microscopies.

Contexte de travail

The work will mainly be carried out at the CNRS Coordination Chemistry Laboratory (UPR 8241) in the team "ALAMBIC: Alzheimer, amyloids and bioinorganic chemistry" led by Dr. Christelle Hureau in the framework of a collaborative ANR involving two other partners (ANR MASAI). The project will benefit from the infrastructures of the team, the host laboratory (Laboratoire de Chimie de Coordination, UPR 8241) and the platforms available in Toulouse (Institut de Chimie de Toulouse).

Contraintes et risques

Handling of chemicals.

Informations complémentaires

In addition to the response via the CNRS portal, the applicant is asked to send a CV and a covering letter including the contact details of one or two referees to christelle.hureau@lcc-toulouse.fr and genevieve.pratviel@lcc-toulouse.fr