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Reference : UPR5301-ISACAL-074
Workplace : GRENOBLE
Date of publication : Thursday, July 15, 2021
Scientific Responsible name : Sami HALILA
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The transdisciplinary (Chemistry/Physics/Biology) “SWEET-DISPLAY” project spans from original access towards glyco-amphiphiles, through self-assembly and lectin interactions in solution up to the fabrication & characterization of liquid crystals-based biosensors. The PhD candidate will be in charge of optimizing protecting-free functionalization of carbohydrates issues and to perform the detailed characterization of glyco-amphiphiles for developing a liquid-crystal-based carbohydrate biosensor for lectin/pathogen detection. The PhD will benefit from state-of-the-art processing and characterization platforms available within CERMAV & SyMMES labs to develop her/his research on carbohydrate chemistry and their interactions with specific lectins from pathogens and will facilitate the implementation towards liquid crystals-based biosensors by interacting with our partners.
A PhD position devoted to functional glyco-amphiphiles is available in October 2021 as a part of the French National Research Agency (ANR) collaborative project “SWEET-DISPLAY” coordinated by Dr. Sami Halila in Grenoble (France). This research project combine expertise and skills of CERMAV Lab [UPR5301-CERMAV (CNRS/Univ. Grenoble Alpes): Dr. S. Halila and Dr. A. Imberty: chemistry & physical-chemistry of Carbohydrates and Glycobiology] and SyMMES Lab [UMR5819-SyMMES (CEA/CNRS/Univ. Grenoble Alpes): Dr. P. Rannou: chemistry and physics of functional liquid crystals. The PhD position is funded for three years by ANR and can start in October 2021.
The PhD candidate should preferably hold a Master degree in organic chemistry with a first experience in a Laboratory on modification and characterization of carbohydrates interacting with carbohydrate-binding proteins. Knowledges on binding assays or/and liquids crystals are expected. She/He must be an enthusiastic and dynamic researcher with scientific creativity. Excellent communication and writing (English) skills are equally important criteria with respect to academic qualifications and scientific merit for the selection of the PhD.
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