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PhD: Thermodynamical and rheological characterization of DNA gels for rational design (M/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mercredi 14 juillet 2021

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General information

Reference : UPR2940-ELOBER-041
Workplace : GRENOBLE
Date of publication : Wednesday, June 2, 2021
Scientific Responsible name : GUILLOU Hervé
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

This project tackles the rational design of functional DNA hydrogels. For few years, DNA, a molecule commonly associate with the genome, emerges as an ideal polymer to elaborate soft materials. The nucleic acid sequences can be designed to fold into a variety of programmed shapes. In this project we focus on DNA hydrogels assembled from DNA sequences targeting applications in medecine and bioengineering.
The project consists of exploring the thermodynamical and rheological properties of DNA hydrogels with differential scanning calorimetry, high throughput microdroplets microrheology and rheology under flux. Our goal is to identify and quantify the relevant energy scales and to relate them with models and simulations in order to improve the rational design of functional and programmable biomaterials.

This PhD project targets the quantification of the energy scales (thermodynamical, elastical, dissipative and fracture) in these new biomaterials with a controlled architecture and to link them together through models and simulations in order to develop the rational design of functional biomaterials.

We are looking for a curious and proactive candidate that feels confortable to work in various laboratories and in an international context. Skills in experimental and statistical physics, thermodynamics, data analysis and biotechnologies will be developped during the PhD. A fluent english level is mandatory.

Work Context

The candidate will perform the measurements based on the existing setups available in the three laboratories:
- at Institut Neel (Grenoble, France) differential scanning calorimeters as well as isothermal titration calorimeters,
- at LIMMS (Tokyo, Japon) high throughput microdroplets microrheological characterization
- and at Institut Lumière Matière out of equilibrium rheometers will be used.

The PhD thesis will be undertaken in an international context (France – Japan) and is highly interdisciplinary (biophysics, data analysis, simulations).

• Institut Néel (Grenoble, http://neel.cnrs.fr/) is a CNRS laboratory focused on fundamental condensed matter physics associated with the University Grenoble Alpes. About 450 collaborators works in the lab on problems related with functional materials, biophysics, spatial and quantum physics.

• Laboratory for Integrated Micro-Mechatronics Systems (Tokyo, https://limms-tokyo.org/), is an international research unit on MEMS and NEMS (Micro- and Nano-Electro-Mechanical Systems) operated in joint names of France, CNRS – INSIS, and Japan, IIS, The University of Tokyo. Our Research activities are aimed at adressing societal issues: Integrative Bioengineering, BioMEMS for translational research, Energy and Smart sensors in society

• Institut Lumière Matière (ILM, Lyon , http://ilm.univ-lyon1.fr/) is a joint laboratory between the CNRS and the University Claude Bernard Lyon 1. The research developped involves more than 300 fellows at the frontiers of engineering, biology, soft matter, nanosciences, health, energy and environment.

Host groups:
"Thermodynamique et Biophysique des Petits Systèmes" at Néel, Genot's lab at LIMMS and Liquides et Interfaces at ILM.

• Supervisors:
- Dr. Hervé GUILLOU, Institut Néel, PhD director
- Dr. Anthony GENOT, LIMMS, co-director
- Pr. Catherine BARENTIN, iLM, co-director

Additional Information

Applications imply the deposit of a CV and motivation letter including references.

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