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Doctoral contract (M / F): Total synthesis of glycosylated polyene macrolactams

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Français - Anglais

Date Limite Candidature : vendredi 24 septembre 2021

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General information

Reference : UPR2301-STENOR-002
Workplace : GIF SUR YVETTE
Date of publication : Friday, September 3, 2021
Scientific Responsible name : Stéphanie Norsikian
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 November 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The project is to design the first total syntheses of natural products having a very tight polyene macrolactam structure and beta-glycosylated by an aminosaccharide or diaminodisaccharide. Most of these molecules exhibit antibiotic activity (Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus and S. lentus) of interest in the context of the emergence of antibiotic resistance.

Work Context

The Institut de Chimie des Substances Naturelles is a dedicated CNRS Research Unit whose research axes are chemistry and biology. It is part of the University of Paris-Saclay which, since 2015, brings together research and educational establishments in the south of Paris. The ICSN is located on the Gif-sur-Yvette campus and has around 120 agents, including 74 permanent staff spread over 3 buildings. Within the Chemobiology Department, the recruited agent will join the "Probes and Modulators for Biological Targets" team made up of 1 IT, 6 CH and 5 CDD / doctoral students. He / she will be placed under the hierarchical authority of the team leader and the project will take place under the direction of Stéphanie Norsikian. The laboratory is equipped with all the necessary instruments for the realization of the project (HPLC, automatic flash chromatography, microwave synthesis reactor, freeze-dryer, rotavap, etc.). Several analytical platforms are present on the site and provide state-of-the-art instruments: NMR (300, 500MHz), mass spectrometry (LCMS, HRMS) and X-ray diffraction.

Constraints and risks

The project involves Hygiene and Safety constraints related to the handling of chemicals. The experiments will be carried out in a laboratory equipped with hoods.

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