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Reference : UPR22-JEALUT-002
Workplace : STRASBOURG
Date of publication : Tuesday, June 16, 2020
Scientific Responsible name : Jean-François Lutz
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The main objective of this PhD thesis will be the synthesis of digital polymers, which are macromolecules that store information. Sequence-defined poly(phosphodiester)s will be synthesized in this work by automated solid-phase chemistry. This works will include both monomer and polymer synthesis. An excellent level in experimental organic chemistry is required for this work. Theoretical knowledge in polymer science is also wished.
This PhD thesis is proposed in the context of a collaborative project funded by the French National Agency for Research (ANR). This collaboration network includes the Institut Charles Sadron of Strasbourg (workplace for the PhD student), the Institut de Chimie Radicalaire of Marseille et the Institut Pluridisciplinaire Hubert Curien of Strasbourg. The PHD student will interact with researchers and students from all these institutions.
Constraints and risks
This PhD work will include mainly chemical laboratory tasks. Theoretical and practical knowledge (e.g. master internship) in chemical synthesis are mandatory. The candidate shall : (1) be able to prepare chemical reactions, (2) know all standard organic purifications techniques (TLC, column chromatography, extraction, recrystallization) and (3) be familiar with standard molecular charcaterization tools (NMR, FT-IR, MS...).
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