PhD Researcher in Cell Biology (M/F)
New
- FTC PhD student / Offer for thesis
- 36 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biologie Intégrative de la Cellule
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
91198 GIF SUR YVETTE
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 23 July 2026 23:59
Job Description
Thesis Subject
Alzheimer's disease is associated with early alterations in cholesterol metabolism, lipid droplet accumulation, mitochondrial dysfunction, and defective autophagy, particularly in APOE4 carriers. This PhD project aims to investigate how membrane contact sites between the endoplasmic reticulum, mitochondria, and lipid droplets coordinate cholesterol trafficking, storage, and turnover through autophagic pathways. Using advanced imaging, cell biology, and biochemical approaches in human iPSC-derived astrocytes and neuronal models, the project will characterize the molecular mechanisms linking membrane contact site dynamics, autophagy, and cholesterol homeostasis in Alzheimer's disease. The work may uncover novel therapeutic targets for restoring cellular lipid balance in neurodegeneration.
Your Work Environment
The PhD project will be carried out in the Lipid Trafficking and Membrane Contact Sites team at the Institute for Integrative Biology of the Cell (I2BC, Université Paris-Saclay), under the supervision of Francesca Giordano and co-supervision of Emmanuel Nivet (INP Marseille). The student will benefit from a highly collaborative and multidisciplinary environment combining expertise in membrane contact sites, lipid metabolism, autophagy, neurodegeneration, advanced microscopy, stem cell biology, and cell biology. The project will leverage state-of-the-art imaging facilities and established human iPSC-derived models of Alzheimer's disease. The work is supported by dedicated funding from an ANR research grant and Alzheimer's disease foundations, providing access to cutting-edge technologies, training opportunities, and national and international scientific networks.
Constraints and risks
The project involves standard biological and biochemical experiments performed in a regulated laboratory environment. Activities include work with human iPSC-derived cell lines, cell culture under L2 conditions, chemical reagents, and advanced microscopy platforms. Appropriate training in laboratory safety, biosafety procedures, and equipment use will be provided before experimental work. No specific risks beyond those routinely associated with cell biology and biochemical research are anticipated.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR9198-FRAGIO-003 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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