PHD Contract in Structural Biology and Biochemistry (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biologie Intégrative de la Cellule
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
91198 GIF SUR YVETTE
Contract Duration
36 months
Date of Hire
01/12/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 20 October 2026 23:59
Job Description
Thesis Subject
Drug resistance and toxicity highlight the urgent need for new strategies to discover and engineer bioactive natural products. This project aims to determine the molecular mechanism of pyrimidine ring assembly during the biosynthesis of the glycopeptide antibiotic/anticancer drug bleomycin by a nonribosomal peptide synthetase (NRPS) assembly line. Pyrimidine moieties are essential for the activities of numerous drugs, while the modular architecture of NRPSs makes them attractive platforms for bioengineering. Our project will combine biochemistry, structural biology, and chemical synthesis to define the catalytic mechanisms, structures, and protein-protein interactions responsible for NRPS-mediated pyrimidine formation. By elucidating how specialized NRPS domains cooperate to construct complex heterocycles, we will reveal the molecular basis of their unusual chemistry and the interaction interfaces that govern biosynthetic efficiency. These findings will establish a framework for rational NRPS engineering to produce novel pyrimidine-containing natural products with improved bioactivities, advancing sustainable approaches to combat drug resistance and toxicity.
Your Work Environment
The I2BC is a very large joint research unit of the CNRS, CEA, and Université Paris Saclay, established on January 1, 2015. Located at the Gif, Orsay, and Saclay sites, the unit has an average staff of approximately 650 people distributed across 5 scientific departments, 43 research teams, and 17 high-level technology platforms.
The doctoral position is available in the “Structures and Functions of Hybrid Assembly Chains of Natural Products” team, which is part of the Department of Microbiology and consists of one CR-level researcher.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR9198-CHROUL1-162 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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