PhD in Cell Biology (M/F)
New
- FTC PhD student / Offer for thesis
- 36 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biologie Intégrative de la Cellule
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
91198 GIF SUR YVETTE
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 15 July 2026 23:59
Job Description
Thesis Subject
Collective cell migration plays a key role in morphogenesis, tissue regeneration, and tumor progression. To maintain their speed and direction, cells must coordinate their movements, which requires the directional propagation of signals within the cellular group. In this context, the actomyosin cytoskeleton transmits mechanical information to cell–cell adherens junctions (AJs) and cell–matrix focal adhesions (FAs). Our recent work has shown how mechanosensors at AJs and FAs—α-catenin and talin, respectively—convert forces transmitted by actomyosin into molecular signals by forming stable complexes with vinculin, thereby promoting actin polymerization. We hypothesize that this mechanosensitive actin assembly in turn activates neighboring mechanosensors, enabling the propagation of vinculin binding as a mechanical signal. Our objective is to determine the respective contributions of FA and AJ mechanosensors, as well as their interaction, in the spatiotemporal propagation of the information required for collective migration. To this end, we will combine CRISPR-Cas9 genome editing approaches, optogenetic tools, and advanced quantitative fluorescence imaging techniques applied to MDCK cells undergoing collective migration.
Your Work Environment
The thesis will be carried out at the Institute of Integrative Cell Biology (I2BC), and more specifically within the Cytoskeleton Dynamics and Motility group of the Department of Cell Biology. The I2BC is a joint research unit under the supervision of Université Paris-Saclay, the CEA, and the CNRS. The PhD candidate will obtain a doctoral degree from Université Paris-Saclay.
Constraints and risks
There are no specific constraints or particular risks associated with the position.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR9198-CHRLEC-007 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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