PhD Bioinformatics M/F
New
- FTC PhD student / Offer for thesis
- 36 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Génétique Humaine
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
34396 MONTPELLIER
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 22 April 2026 23:59
Job Description
Thesis Subject
From a single gene, our cells can produce different versions of a protein through a mechanism called "alternative splicing." Genetic mutations can disrupt this system, but in highly variable ways: the same mutation may be harmless in the liver while causing a serious disease in neurons. Currently, no tool can predict these effects according to cell type, leaving many genetic mutations "uninterpretable" in clinical settings. Our project will develop an artificial intelligence approach capable of predicting, for each mutation and each cell type, its impact on splicing. We will combine two areas of expertise: fine-grained analysis of DNA sequences (computer science) and understanding of cellular identity through embeddings trained on millions of cells (bioinformatics). By applying this approach to the large-scale biological and clinical datasets at our disposal, this advance will pave the way for more precise genetic diagnosis and therapies targeting the right cells at the right time.
Your Work Environment
The Institute of Human Genetics (IGH, UMR 9002 CNRS – University of Montpellier) is one of the most renowned biology research institutes in Europe. Bringing together approximately 210 people across 24 research teams, the IGH conducts cutting-edge fundamental research in the fields of genome dynamics, epigenetic regulation, RNA biology, and molecular pathologies, with a strong commitment to translating these advances into clinical applications. The doctoral student will be hosted within the "Machine Learning and Gene Regulation" team led by William Ritchie, specializing in bioinformatics and post-transcriptional regulation. The scientific environment at the IGH — international seminars, journal clubs, state-of-the-art technological platforms, and proximity to the Montpellier University Hospital (CHU) — will provide an ideal setting for this interdisciplinary project at the interface between artificial intelligence and genomics. The institute also has high-performance computing infrastructure (hundreds of CPU cores, over 100 TB of storage) essential for processing the massive single-cell sequencing data at the heart of the project.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR9002-WILRIT-003 |
|---|---|
| CN Section(s) / Research Area | Organisation, expression and evolution of genomes Bioinformatics and systems biology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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