Faites connaître cette offre !
Reference : UMR8520-FRELEF-035
Workplace : VILLENEUVE D ASCQ
Date of publication : Monday, September 30, 2019
Scientific Responsible name : Dr AMAR ABDERRAHMANI
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 December 2019
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
A three-years doctoral fellowship is available in the NanoBioInterfaces (NBI) group (http://pang.univ-lille.fr/partners/nanobiointerfaces-team-nbi) at IEMN. The candidate will be supervised by two research teams gathering chemists, cell and molecular biologists and physiologists. This project aims at investigating the role of a hepatocyte growth factor (HGF) mimetic using engineered nanoparticles in the pancreatic islet beta cells function and in mouse models of obesity and diabetes. The data will enable us to examine whether this c-MET agonist protects beta cells against death in diabetes condition and assess the underlying signaling mechanisms. Multiple approaches including islet isolation, beta cell dispersion, peptide synthesis, global “omics”, etc,..will be applied to achieve the goals. Appropriate training will be given in all the techniques described.
The candidate will maintain constructive working relations with the two interdisciplinary teams involved in this project.
The project, awarded by the I-SITE ULNE (http://www.isite-ulne.fr/index.php/fr/app/) and entitled 'Effect of a novel MET agonist for combating beta cell decline in type 2 diabetes', will run from November 2019 and is part of a growing portfolio of diabetes research at the University of Lille.
We are looking for a candidate who:
• is curious and has a keen interest in diabetes to complement and broaden existing expertise.
• will work closely with other researchers at the University of Lille and Pasteur Institute.
Candidates are required to have a training in the field of molecular and cell biology. Experience in animal experimentation will be very much appreciated. The position provides an excellent opportunity to a highly motivated young researcher to work in a world-class competitive and supportive collaborative environment dedicated to metabolic diseases.
Please provide the names and email addresses of three references
IEMN is a research institute of 450 people. Its research activity is multidisciplinary and covers a wide spectrum from material physics to telecommunications systems.
The NanoBiointerfaces group is one of 22 research groups at IEMN. It is located on the CNRS Haute Borne Campus in Villeneuve d'Ascq, in the IRI building.
We talk about it on Twitter!