Thèse en neurophysiologie et imagerie (H/F) / PhD in neurophysiology and imaging (M/F)
New
- FTC PhD student / Offer for thesis
- 36 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Développement, Adaptation, Vieillissement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
75252 PARIS 05
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 24 July 2026 23:59
Job Description
Thesis Subject
Mechanistic insights and optimization of synchronized respiratory stimulation as a therapeutic intervention to prevent diaphragm atrophy: longitudinal analysis via MRI
Your Work Environment
Cervical spinal cord injuries (SCI) severely impair both motor and respiratory functions, often leaving patients dependent on mechanical ventilation (MV), which in turn worsens diaphragm dysfunction and limits recovery. A new non-invasive, breathing-synchronized stimulation system (rSynES), developed by Dr. Isabelle Vivodtzev, targets accessory respiratory muscles and has shown promising results in improving respiratory function. Suggesting that it may activate spinal networks.
This PhD project aims to investigate the underlying mechanisms of rSynES-induced recovery using a mouse model of cervical SCI, through longitudinal assessment of molecular and cellular changes. Advanced imaging techniques, including structural and functional-MRI, developed by Dr. Emmanuel Barbier (GIN director), will be used to optimize rSynES and monitor neuronal changes over time at the lesion site.
In addition, we will study the mechanisms of neuroplasticity. For example, we will assess the reorganization and survival of motor neurons using synaptic markers and analyses of nerve fiber regrowth. Tracing techniques will allow us to observe the connections from the brain to the spinal cord. Inflammation will be measured using immunostaining and western blot."
A significant part of the is thesis (1 year) will be carried out at the GIN - Grenoble institute of neuroscience- located in Grenoble, a multidisciplinary center situated at the interface between physics and biology. Consequently, the candidate must demonstrate skills and a strong interest in these two disciplines. Additionally, the candidate must show an aptitude for data processing and numerical simulation. Proficiency in programming tools (Matlab, Python, C++) is essential, and knowledge of NMR/MRI would be a valuable asset.
Constraints and risks
For this thesis, it will be required to spend a year (10 to 12 months) in Grenoble. Please note that the potential associated costs cannot be covered by the laboratory."
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8263-ISAVIV-007 |
|---|---|
| CN Section(s) / Research Area | Integrative plant biology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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