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PhD proposal in Physiology – Neurosciences (M/F)

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR8251-CLAMAR-001
Workplace : PARIS 13
Date of publication : Wednesday, June 17, 2020
Scientific Responsible name : Claire Martin
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Deregulation in the control of food intake is a major contributor to the rising numbers of obese people. Smell is one of the most relevant sensory cues predicting food and is likely to play a key role in food choice and food consumption. The relation between olfactory system processing and food intake has been established and studies have shown that the olfactory system is at the crossroad between sensory processing and metabolic sensing.
The objective of this project is to assess the influence of trigeminal detection on multisensory neural processing during olfactory perception and the role of this process on obesity. In this new area of research we seek to establish the link between olfaction and obesity in mice.
Specific Aims: 1) To assess the impact of trigeminal activation on OB processing during olfactory perception. 2) To assess multisensory cortical neural processes during olfactory perception. 3) To inform the role that functional changes in trigeminal aspects of olfaction have on obesity.
This thesis is in the framework of the UChicago – CNRS Collaboration Program : Multisensory Cognition in the Nose: Interactions between Olfactory and Trigeminal Senses.
Due to the collaborative and international nature of the project, good communication skills in English are required. The recruited doctoral student will be required to transmit his knowledge to other students (Master, Doctorate) and to present his work at an international congress.

Work Context

The candidate will work in the team Central Control of Feeding behavior and Energy Expenditure (leader S. Luquet) in the Biologie Fonctionelle et Adaptative Unit (Université de Paris CNRS UMR8251). The core approach of the team is to use the power of modern molecular genetic tools in integrated approaches to dissect out the role of neuronal circuits in the control of feeding behavior, notably in its sensory and motivational components.

Constraints and risks

The candidate will have to spend at least one month in the laboratory of our collaborator in Chicago (USA)

Additional Information

The candidate must hold a master's degree in Physiology with solid knowledge in neuroscience and if possible in nutrition / metabolism.
Due to the collaborative and international nature of the project, good communication skills in English are required. The recruited doctoral student will be required to transmit his knowledge to other students (Master, Doctorate) and to present his work at an international congress.
Applications must include a detailed CV; one or two references (people who may be contacted); a cover letter of one page; a one-page résumé of the dissertation for the Masters; grades for the Masters 2.

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