Reference : UMR8246-DONLI-001
Workplace : PARIS 05
Date of publication : Wednesday, September 21, 2022
Scientific Responsible name : D LI
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 12 October 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Astrocyte signaling in brain energy balance center
Brain regulates body energy balance and energy metabolism. Understanding the signaling pathways will identify central targets ameliorating metabolic disorders. While diverse neuronal pathways are unveiled, the function of astrocytes in hypothalamus metabolic center is largely unresolved. Combining mouse genetics, in vivo deep brain imaging and metabolic behavioral readout, this project aims at parsing the signaling basis underlying astrocyte participation in the central control of energy metabolism.
The Neuroscience department Paris Seine (CNRS UMR8246/Inserm U1130) is centered on analysing the formation and plasticity of neural circuits and neural systems in order to decipher fundamental aspects of brain and spinal cord neurophysiology, and the resulting behaviors. This should unravel the molecular and cellular mechanisms underpinning the differentiation and functional insertion of neurons into developing neural networks, and the remodelling of these networks in normal or pathological conditions.
Constraints and risks
This position is for a doctoral study, lasting 3 years, and will perform imaging and metabolic assessment of astrocytes under ex vivo and in vivo conditions. The contract will be signed with CNRS Paris center under all legal conditions.
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