Description du sujet de thèse

Biomolecular condensates, dynamic assemblies and key players in cell organization
Cells contain millions of biomolecules that interact to perform essential functions such as
functions such as energy production and waste recycling. A key question is
how these molecules come together at the right time and in the right place to perform these
processes. Biomolecular condensates, dynamic micrometric assemblies, are central to cellular
central to cellular organization. Recent experiments have shown that phase transitions
could explain how biomolecules can condense into dynamic assemblies.
assemblies. Examples as diverse as the formation of viral factories and stress granules, as well as
as neuronal synapses, are increasingly seen to be regulated by phase transitions.
phase transitions. Despite major advances, their quantitative study remains limited. Biomolecular
condensates are complex objects, and their biochemical composition and dynamics remain
poorly understood. The development of new analysis and manipulation tools is therefore essential to better understand their cellular role.
their cellular role.

Contexte de travail

The PhD student will be hosted by the Analysis and Engineering of Life team of the CPCV laboratory, and will benefit from the infrastructures of the host team and the ENS Chemistry Department (biotechnology laboratory, optical microscopy, etc.). He/she will benefit from excellent conditions for participation in training courses, summer schools and national and international conferences.ogies, microscopie optique, …). Il/elle bénéficiera d'excellentes
conditions pour participer à des formations, écoles d'été, et conférences nationales et internationales.

Contraintes et risques

RAS

Informations complémentaires

application in ADUM
https://adum.fr/candidature/