Doctorant (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut Cochin
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
75014 PARIS 14
Contract Duration
36 months
Date of Hire
01/11/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 28 August 2026 23:59
Job Description
Thesis Subject
Genome copy number increase (i.e. polyploidy) is frequent in a wide range of tissues, in both physiological and pathological contexts. During development, Drosophila salivary glands undergo programmed endoreplication and reach a ploidy level as high as 1300C. Ploidy increase is often hypothesized to increase the cell's biosynthetic capacity, but experiments instead showed that the mass-normalized protein synthesis rate of large (64N) polyploid cells is the same as that of diploid (2N) cells. Whole-genome duplication is also the second most common alteration leading to tumorigenesis, but its energetic consequences remain poorly understood. We hypothesize that ploidy-driven cellular enlargement may alter cells' energy allocation. This PhD project will focus on studying energy allocation and ATP production rate in different polyploid systems.
Your Work Environment
The team « Quantitative Biology of Cells and Embryos » is part of the Institut Cochin
located in the center of Paris, 22 rue Méchain – 75014 Paris, France.
team leader: Clotilde Cadart
https://institutcochin.fr/equipes/biologie-quantitative-cellule-et-embryon.
The Institut Cochin is a research center affiliated to INSERM, CNRS, Université Paris
Cité. The Institut Cochin is composed of 41 teams and 10 core facilities.
www.institutcochin.fr.
Constraints and risks
L2 level experiments.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8104-CLOCAD-001 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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