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M/F - PhD - Permeability and mechanical properties of a lipid bilayer under a 20 atmosphere osmotic gradient

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 1 juillet 2021

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General information

Reference : UMR8023-FREPIN-002
Workplace : PARIS 05
Date of publication : Thursday, June 10, 2021
Scientific Responsible name : Frédéric Pincet
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Lipid bilayer membranes are semi-permeable, meaning water can cross them but not ions. Hence, when the two neighboring media do not have the same osmolarity, water crosses the bilayer towards the side with the highest osmolarity. We have made a setup in which a lipid bilayer suspended between two microfluidic channels is able to withstand an intriguingly high osmotic gradient: more than one molar across the 5 nm membrane, i.e. more than 20 bars in pressure. How can the membrane resist such high forces? How are the flows compared to the predicted ones? What is the shape of the membrane? These are the questions that will be addressed during this PhD.

Work Context

This PhD is part of the international collaborative project funded by a Synergy ERC LiquOrg. The PhD student will be supervised by Frédéric Pincet. It will take place mainly at LPENS in Paris and occasionally it will involve working at the Rothman lab at UCL in London, the Lopez-Montero lab at UCM in Madrid and the Malhotra lab at CRG in Barcelona.

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