PHYSICS OF ADAPTATION PROCESSES CONTROLLING TISSUE PHYSIOLOGY M/F
New
- FTC PhD student / Offer for thesis
- 36 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de physique de l'ENS
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
75005 PARIS 05
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 24 April 2026 23:59
Job Description
Thesis Subject
Across all stages of health and in pathophysiological conditions, changes in gene and protein regulation drive changes in cell state to allow for diversification of physiology required in multicellular life. These changes are driven by the local cellular environment which, in the case of multicellular tissue, includes mechanical and biochemical cues from surrounding cells as well as the surrounding extracellular environment. How local environmental cues, which operate through mechanotransduction and biochemical signaling networks at seconds to minute time scales, alter transcriptional changes at long time scales is not well understood. The PhD candidate will develop theoretical and data analysis method to interpret single-cell data from endothelial tissues and to produce a working model of how phenotypical changes occur over long time scales. To do this, we will build on a landscape picture of stochastic gene expression dynamics inferred from data using modern machine learning techniques. The results will inform us about how processes on different timescales coordinate to result in the diversity of observed cellular responses.
Your Work Environment
The student will work in the group of T. Mora and A. Walczak that works on various questions of theoretical biophysics, as well as in the broader biophysics groups at LPENS and at the ENS bio institute. As part of our collaboration, the group of Margaret Gardel at the University of Chicago will produce single-cell expression data from endothelial tissues to understand how the cell's transcriptome impacts the morphological dynamics.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8023-ALEWAL-016 |
|---|---|
| CN Section(s) / Research Area | Physical chemistry, theoretical and analytic |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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