PhD (M/F) en Chimie

Job Description

Thesis Subject

This project aims at identifying and quantifying the species produced during irradiation in the presence of nanoparticles. For that, the student will develop new sensitive quantification methods to analyze species such as O2-, 1O2. Then determination of radical yields produced during irradiation along the track in high-LET ion beam with sub-millimeter resolution will be performed. The results obtained should help us to describe radiosensitization mechanisms of metallic NPs at the molecular level and will be compared with theoretical and computational modeling results through close collaboration with other partners within the MS-RADAM network.

The different tasks of the project are:
• Nanoparticles synthesis, functionalization and characterization
• Elaboration of protocols for sensitive quantification of radicals and molecular species produced by radiolysis in the presence of nanoparticles (O2-, 1O2….)
• Quantify chemicals species emitted for different beam types (photons, electrons, ions) and setting (along the Bragg peak)
• Quantification of the impact of Cerenkov light

Your Work Environment

In the medical field, nanoparticles can be considered as very important added-values for gene or drug delivery, imaging, and radiotherapeutic treatments. For radiotherapy, the approach to decrease side effects in normal cells is to deposit higher energy in the tumor by inclusion of metallic nanoparticles. Despite the intense literature of cell-death induced by irradiated nanoparticle, clinical applications is still not effective. The main reason for that is the absence of consensus on the mechanism responsible for deleterious species at the vicinity of the nanoparticles. Therefore, this project aims at identifying and quantifying the species produced during irradiation in the presence of nanoparticles.

Constraints and risks

Eligibility criteria

(a) The candidate must not have already earned a doctoral degree.

(b) At the time of recruitment, the candidate must not have lived or conducted their main activities (work, study, etc.) in the country of recruitment for more than 12 months in the 3 years prior to the recruitment date/start date of the activities.

(c) The candidate must meet ALL admission requirements for the PhD program at Université Paris-Saclay. These requirements must be fulfilled at the start of the contract.

(d) Candidates of all nationalities and genders are welcome to apply.

(e) In line with MSCA requirements, candidates must be willing to undertake international mobility (four months) during the project implementation. This is a mandatory requirement.

Compensation and benefits

Compensation

2300 € gross monthly

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions