Ph.D. Student (M/F) in Organic Synthesis
New
- FTC PhD student / Offer for thesis
- 36 mounth
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Centre Interdisciplinaire de Nanoscience de Marseille
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
13288 MARSEILLE 09
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 19 June 2026 23:59
Job Description
Thesis Subject
Mitochondrial diseases are rare disorders characterized by an energy deficiency that primarily affects the brain, muscles, and heart. Current diagnostic methods rely on invasive and often late-stage procedures, highlighting the need for more sensitive and functional tools. In these diseases, mitochondria exhibit decreased membrane potential, impaired respiration, abnormal morphology, and a disorganized network. Mitochondrial imaging therefore appears to be a promising approach for detecting these dysfunctions. However, existing Mitotrackers depend on membrane potential and consequently fail to accurately identify altered mitochondria.
The aim of this PhD project is to develop a family of phenazinium-based Mitotrackers that are completely membrane potential-independent, stable, and non-toxic. A library of molecules will be synthesized in Marseille (CINaM, under the supervision of Olivier Siri) and tested in vitro in Angers (under the supervision of Guy Lenaers) to assess their diagnostic sensitivity, confirm the absence of toxicity, and establish structure–biological property relationships.
Your Work Environment
This PhD project lies at the interface between chemistry and biology and is structured around two work packages: WP1 = synthesis and physicochemical characterization of a family of fluorescent molecules (CINaM, Marseille); WP2 = in vitro evaluation of their diagnostic sensitivity (MITOLAB, Angers).
Constraints and risks
The candidate must have a strong background in organic synthesis as well as basic knowledge of biology. Based primarily in Marseille, the candidate will also be required to travel to Angers in order to receive training in cell culture and confocal microscopy techniques during the initial phase, and subsequently to carry out in vivo evaluation of the impact of the synthesized molecules on mitochondrial physiology. These trips, estimated at three to four per year and lasting from one to four weeks, require good mobility and adaptability.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7325-VALSEV-162 |
|---|---|
| CN Section(s) / Research Area | Molecular architectures: syntheses, mechanisms and properties |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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