PhD Student (M/F) in Hematopoietic Stem Cell Biology and Aging
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Recherche sur le Cancer et le Vieillissement, Nice
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
06000 NICE
Contract Duration
36 months
Date of Hire
04/01/2027
Remuneration
2300 € gross monthly
Apply Application Deadline : 09 October 2026 23:59
Job Description
Thesis Subject
Hematopoietic stem cells (HSCs) ensure the lifelong production of all blood cell types. With age, HSCs undergo functional and molecular changes that impair their regenerative capacity and contribute to the development of age-related hematological disorders.
This PhD project aims to understand the molecular mechanisms underlying HSC senescence and functional aging, as well as their consequences for hematopoiesis. The PhD candidate will investigate the links between inflammatory signaling, cellular stress responses, senescence, and the maintenance of HSC function.
The project will combine mouse models with cellular and molecular biology approaches, flow cytometry, and transcriptomic and epigenomic analyses.
The ultimate goal is to identify the mechanisms driving the age-associated loss of stem cell function and to explore strategies to preserve or restore functional hematopoiesis.
Your Work Environment
The PhD candidate will work within the **“Molecular Hematology – Blood Signals”** team, under the supervision of **Dr Eirini Trompouki**, at the **Institute for Research on Cancer and Aging of Nice (IRCAN)**.
IRCAN is a multidisciplinary research institute located at the heart of the Pasteur University Hospital campus in Nice. Research at IRCAN aims to understand the biological mechanisms linking aging to age-related diseases, particularly cancer. Particular emphasis is placed on the molecular and cellular mechanisms of aging, stress responses, inflammation, epigenetics, and the cellular microenvironment.
The **“Molecular Hematology – Blood Signals”** team investigates the molecular mechanisms controlling the development, maintenance, regeneration, and aging of the hematopoietic system, with a particular focus on hematopoi
Constraints and risks
Constraints and Risks
The position involves working with mouse models and conducting cellular and molecular biology experiments. The PhD candidate may handle biological samples, chemicals, and reagents associated with biological or chemical risks.
Some experiments may require working hours to be adapted to the constraints of experimental protocols.
All activities will be conducted in accordance with health and safety regulations, institutional procedures, and current regulations governing animal experimentation. The necessary training and authorizations will be provided according to the requirements of the project.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7284-EIRTRO-012 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
Create your alert
Don't miss any opportunity to find the job that's right for you. Register for free and receive new vacancies directly in your mailbox.