Doctorant / Doctorante 3 ans (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biologie Valrose
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
06108 NICE
Contract Duration
36 months
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 24 August 2026 23:59
Job Description
Thesis Subject
Nutrients derived from food fulfill three major functions: structural (building), energetic, and regulatory. While the first two are well established, the regulatory function remains largely unexplored. In particular, the nutrients that exert regulatory roles, as well as their mechanisms and sites of action, are still poorly characterized.
Recent work from our team has revealed a direct link between circulating citrate, a metabolite derived from dietary intake, and male gametogenesis in Drosophila. We discovered that the conversion of citrate into acetyl-CoA controls the stability of key proteins involved in spermatogenesis through N-terminal acetylation. Remarkably, this metabolic regulation affects only a subset of proteins and is not observed in the female germline.
The objective of this project is to broaden our understanding of the specific mechanisms that couple nutrition, metabolism, and cellular differentiation. Using Drosophila spermatogenesis as a model system and combining genetic and biochemical approaches, this project aims to: (i) elucidate the specificity of metabolic regulation through the model of N-terminal acetylation, and (ii) identify novel metabolic pathways involved in the control of male fertility.
The planned experiments will include genetic approaches, tissue dissections, Western blot analyses, immunostaining, and confocal microscopy. This integrated strategy will provide a detailed understanding of the molecular mechanisms linking environmental factors—particularly nutrition—to male fertility.
Your Work Environment
Our team is part of the Institut de Biologie Valrose (IBV), a dynamic research institute located on an urban campus in the heart of Nice, on the Mediterranean coast. The institute brings together 25 research groups and more than 200 members from a wide range of disciplines and nationalities. English is the working language.
IBV offers a collegial and stimulating research environment, modern facilities, a high level of technical expertise, and numerous opportunities for interdisciplinary collaboration.
For more information, visit the IBV website: http://ibv.unice.fr/ and our team page: http://ibv.unice.fr/research-team/hudry/.
Constraints and risks
NA
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7277-BRUHUD-011 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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