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"Screening and separation of metal chelating peptides in peptide hydrolysates "

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Français - Anglais

Date Limite Candidature : mercredi 8 décembre 2021

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General information

Reference : UMR7274-LATCAN-001
Workplace : NANCY
Date of publication : Wednesday, November 17, 2021
Scientific Responsible name : Laetitia CANABADY-ROCHELLE
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 January 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

"Screening and separation of metal chelating peptides in peptide hydrolysates "
Co-products from agricultural resources are generally rich in protein (around 30%). Initially intended for animal feed, these co-products could be upgraded after protein extraction, followed by their hydrolysis in higher added-value applications. In fact, the peptide hydrolysates produced by enzymatic hydrolysis of proteins constitute a source to be exploited given the presence of bioactive peptides reported in the literature. Thus, various bioactive peptides have been discovered in these protein hydrolysates exhibiting various biological activities (anti-hypertensive, antimicrobial, antioxidant activities, etc.) or other functional activities, including the ability to chelate metals. Depending on the chelated metal ion, various applications can be considered, in particular in nutrition and cosmetics. The objective of this PhD thesis is to produce various peptide hydrolysates, from various protein resources, in order to constitute a library of peptides to explore and to discover new bioactive peptides. Once the hydrolysates have been produced, the second part of this thesis will consist in screening, then separating and identifying the metal chelating peptides. Finally, these peptides will be identified and their biological activities will be evaluated.

Work Context

The Reactions and Process Engineering Laboratory (UMR 7274) is a joint unit of the CNRS and the University of Lorraine created on January 1, 2010 and based in Nancy. Its general scientific objective concerns the study of processes taken as a whole and their complexity. The LRGP develops the scientific and technological knowledge necessary for the design, study, management and optimization of complex processes of physicochemical and biological transformation of matter and energy. The unit has more than 300 people, with nearly 20 CNRS researchers, 80 research professors, 45 technical and administrative staff and 180 non-permanent staff (contract researchers, 85 doctoral students, post-docs, masters.

Constraints and risks

No risk.

Additional Information

Please give CV
Motivation letter
Recommandation letter(s)

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