General information
Offer title : Researcher (M/F) in PhD in optical imaging for biology (H/F)
Reference : UMR7252-PIEBON-004
Number of position : 1
Workplace : LIMOGES
Date of publication : 23 December 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 2 March 2026
Proportion of work : Full Time
Remuneration : 2300 € gross monthly
Section(s) CN : 08 - Micro and nanotechnologies, micro and nanosystems, photonics, electronics, electromagnetism, electrical energy
Description of the thesis topic
Super-resolution imaging in optical microscopy now achieves nanometric resolution without requiring electron microscopy. However, it currently remains limited to the use of fluorescent molecules. Within our team, we are developing super-resolution approaches compatible with label-free imaging (Aguilar et al. 2021).
We have extended this technique to label-free samples and can now observe thick biological samples at rates reaching the kHz range. This will enable the non-invasive study of intact biological tissue dynamics.
The goal of this thesis is to (1) strengthen the setup to make it compatible with high-speed imaging over long durations, (2) optimize system control and develop signal processing tools, and (3) apply it to imaging challenges involving organoids and living biological tissues.
- Hardware (opto-electronics) and software
- Optical alignment
- Model and biological sample imaging
- Microscopy knwoledge
- Optical imaging (theory and experiment)
- Programming (Labview, Python/Matlab)
- Organisation
- Autonomy
- Interdisciplinary skills
Work Context
The XLIM laboratory in University of Limoges is world widely recognized in particular in the field of optics and photonics. The team is working in the Photonic axis and is developing novel optical imaging techniques for biology.
In particular, Pierre Bon is developing novel label imaging techniques for biological tissue studies. The candidate will work is this research team.
The PhD candidate will present his work in international conferences around the world (1 to 3 international trips).
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
Constraints and risks
Restricted area recrutement (ZRR).
handling of biological samples.
laser safety.