Description du sujet de thèse

Tomographic Diffractive Microscopy (TDM) represents state-of-the art in unlabeled optical microscopy, in terms of resolution, and for quantitative measure of sample's optical properties. This technique is even now commercially available, but in simplified versions. Institut Fresnel and IRIMAS collaborate via an ANR grant, in view of further improving the technique. In particular, the importance of working with isotropic-resolution images is vastly overlooked. Even simple quantities such as volumes cannot be accurately measured at micrometric scale in transmission-only microscopy, because of the so-called “missing-cone” problem. Consequently, index of refraction, or species concentrations are even more difficult to measure with precision.

Contexte de travail

We propose two PhD in the frame of this project, one for the present offer based at the Institut Fresnel in Marseille, and the other at IRIMAS in Mulhouse. The goal is to develop a tomographic system with isotropic resolution. Several approaches will be studied : a configuration called 4pi combining systems in reflection and transmission, and a mirror-assisted configuration where the sample will be placed in the vicinity of a mirror to superimpose measurements in transmission and reflection.
The tasks will deal with the experimental development of these set-ups, and also with adapting the 3D image reconstruction procedures to these new configurations.

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