Faites connaître cette offre !
Reference : UMR7247-LUCPEL-002
Workplace : NOUZILLY
Date of publication : Tuesday, March 24, 2020
Scientific Responsible name : Lucie Pellissier
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Autism spectrum Disorders (ASD) are one of the major neurodevelopmental health public issues, affecting more than 1/100 child births worldwide. No approved pharmacological treatment exists relieving social deficits, one of the ASD primary symptoms. Despite its role in the control of social behavior, results of clinical trials using oxytocin administration remain mitigated. Actually, the mechanism underlying oxytocin functions is complex and remains poorly elucidated. The objectives of the PhD projects are 1) unravelling the complexity of oxytocin system, 2) developing antibody fragment to target oxytocin receptors, 3) testing in vivo these antibody fragments to improve social interaction deficits in mouse models of ASD.
The PhD student will use diversified approaches, including molecular biology, G protein coupled receptor pharmacology, antibody fragment display, behavioral studies. During the PhD, three research articles as first author, cooperative articles, reviews and eventually patents are expected. The PhD project will benefit from financial and material support of the Research Unit, the team and the ERC starting grant (2020-2025).
The PhD student will be appointed by the CNRS, one of the most well-established French multidisciplinary research institute in the World. Our unit “Physiology of reproduction and Behavior” is a joint research unit between the CNRS, INRAE, the University of Tours and IFCE, located in the Loire Valley. Our research center is really unique with the possibility to work with many animal models, from rodents to big farm animals. The PhD project will integrate the “System biology and pharmacological innovations” team. Our pluridisciplinary team studies G protein coupled receptor signaling using mathematical modelling, antibody fragment, innovative pharmacology, from molecular and cellular biology to animal models. In addition, this PhD project belongs to one of the key research question of the Laboratory of Excellence (Labex) MAbImprove (http://mabimprove.univ-tours.fr) on the development of therapeutic antibodies in Tours and Montpellier. The PhD project, which is co-financed by the Labex, will benefit of the expertise and fruitful collaborations of the 28 teams and PhD formations from the Labex.
The PhD student will belong to the “school for PhDs” « Health, Biological Sciences and Chemistry of the life» (SSBCV, https://collegedoctoral-cvl.fr) of the University of Tours, for PhD formations and degree.
Constraints and risks
Short-term stay in France and abroad are expected during the employment.
The applicant must have a Master degree (or equivalent) in biology. Strong knowledge in cellular biology/pharmacology and/or Neurosciences is required, with excellent oral and writing skills in English (mandatory) to present in national and international meetings and to write research articles in scientific journals. Knowledge in molecular biology, antibody display or immunology would be advantageous.
We are seeking for a dynamic person who will be able to fully commit in his PhD project, propose new ideas, be curious, with a critical mind, display some autonomy and would be willing to learn new skills.
To apply for the position, please provide a detailed resume (university, formations, skills, internships, the name of two references), a motivation letter (one page), and a summary (one page) and grades of the Master (or equivalent).
The deadline to apply is May 30th of 2020, followed by interviews in June. The PhD project will start in October 2020. The position might start later than originally planned due to sanitary condition.
We talk about it on Twitter!