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Reference : UMR7177-NADBOU-001
Workplace : STRASBOURG
Date of publication : Wednesday, June 9, 2021
Scientific Responsible name : Jean WEISS
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Experimental work and PhD manuscript writing. Design, synthesis, purification and characterization of strapped porphyrin derivatives and functionalized cyclodextrins. Characterization using 1H, 1D et 2D, NMR, UV-visble absorption and emission spectroscopies, electrochemistry and EPR.
The strapped porphyrins will be combined with cyclodextrins that act as protective envelopes for the reactive binding sites of iron(II) porphyrin derivatives. The viability of this concept has been demonstrated by Japanese colleagues (Doshisha, Kyoto), who showed that the reactivity of iron(II) porphyrins can be modulated by the type of assembly. To enhance the association of porphyrins and cyclodextrins, the strapped porphyrins must be functionalized with water-solubilizing groups. Appropriate synthetic methods have already been optimized, therefore synthetic risks are minimal.
Cyclodextrins functionalized on their primary face will be prepared in Strasbourg and functionalization of their secondary face will be carried out in Doshisha. Strapped porphyrins will be prepared in Strasbourg based on established methods. Spectroscopic studies will be done in Strasbourg and in Osaka. The electrocatalytic properties of the iron porphyrins in organic medium and when deposited on electrodes are known, however studies of the complexes in aqueous medium are necessary if sustainable catalysts are to be developed.
Within the framework of international and national collaborations, hemeprotein models for the binding, transport and activation of oxygen will be developed. This project is part of an International Research Project between the CNRS, Unistra and the University of Rennes 1 and will finance up to three, three-month stays in Japan for the Ph.D student during his/her doctorate. The research will focus on the synthesis and noncovalent assembly of functionalized cyclodextrins (in collaboration with Doshisa University, in Kyoto) and strapped porphyrins. The targeted properties of the porphyrin-cyclodextrin assemblies are oxygen binding with efficient discrimination against CO2, the stereoselective oxidation of substrates using O2 activation and the chiral structure of cyclodextrins.
Constraints and risks
Laboratory safety training
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