Reference : UMR7042-JOAWEN-013
Workplace : STRASBOURG
Date of publication : Friday, July 22, 2022
Scientific Responsible name : Joanna Wencel-Delord
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2022
Proportion of work : Full time
Remuneration : 2135 euros
Description of the thesis topic
One of the key issues and challenges of the modern organic synthesis relates to the development of modern, efficient, and sustainable strategy to build up rapidly molecular complexity. On the other hand, the applications of the chiral compounds have been expanding very rapidly over the last years in various fields, including pharmaceutical industry, agrochemistry and material science.
This PhD project targets therefore design and development of sustainable methodologies for asymmetric synthesis. We will focus on the application of the C-H activation type strategies, using mainly abundant and non-toxic 3d-metals such as Co, Mn and Ni. IN order to reach this challenging goal, we will design unprecedented, polyfunctional chiral ligands. The efficiency of such new ligands for asymmetric functionalisation of aliphatic and aromatic ligands will be evaluated.
This PhD project is a part of the prestigious ERC SG project. The candidate will join a young and motivated research group. Our group is international, and we are working in close collaboration with various industrial and academic partners. Our research group is mainly focusing on the development of various approaches for sustainable synthesis.
Our team is a part of CNRS 7042, LIMA laboratory, the largest organic chemistry laboratory in Alsace. Our laboratory is composed of 10 research groups in Strasbourg and Mulhouse (this PhD will be effectuated entirely in Strasbourg). The research topics of the laboratory concerns general synthetic chemistry, from the methodology development to the applications in medicinal chemistry and material science. Our laboratory is perfectly equiped with state-of-the-art apparatus (NMR, GC-MS, chiral HPLC, etc. to conduct this research project efficiently?
Constraints and risks
Standard risks related to the synthetic chemistry
The candidate should possess Master 2 diploma in organic chemistry. Excellent expertise in organic synthesis/catalysis and asymmetric catalysis, together with very good laboratory skills and competences in analytics are required.
Good English level is mandatory.
We are looking for someone extremely motivated, passionate and with good team-spirit
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