Doctorant (M/F) en Biologie
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de Biologie du développement de Villefranche-sur-Mer
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
06234 VILLEFRANCHE SUR MER
Contract Duration
36 months
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 23 September 2026 23:59
Job Description
Thesis Subject
This PhD project will build on ongoing work in the host lab focussed on the identity and fate of stem cell populations in Clytia. This work indicates that multiple stem cell populations co-exist in the jellyfish, which can be traced back to the specialised polyps that produce jellyfish, including a somatic stem cell population and a potential GSC population. The sex determination aspect is based on an older study using wild Clytia collected from the bay of Villefranche indicating that temperature plays a role in determining sex, acting on young polyp colonies and/or early-stage jellyfish. Specifically, this PhD project will: 1) Define at molecular and cellular levels the germline differentiation trajectory from GSCs to germ cells in both male and female jellyfish and polyp colonies; 2) Pinpoint where and when GSCs (or their precursors) first acquire male or female identities 3) Use freshly-generated 'bipotential' colonies (i.e. ones capable of sex-switching) in order to identify key regulatory genes controlling sexual identity within the germ cell lineage in Clytia.
Your Work Environment
The project will combine approaches of bioinformatics, cell biology, imaging and functional genomics. The candidate will exploit existing tools and resources for Clytia. Live imaging approaches in this highly transparent species will allow the movements of stem cells to be followed. The doctoral candidate will generate bulk and scRNAseq data from young jellyfish gonads, as well as gonozooids (specialised polyps within which the jellyfish develop), for both males and females. They will use immunohistochemical, hybridisation chain reaction (HCR), and EdU approaches to visualize GSCs, pre-meiotic cells, and meiotic germ cells in fixed tissue, and to characterize the appearance of different cell populations within the polyp colony and jellyfish. The function of identified regulator genes can be tested using CRISPR/Cas9 Knockdown.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7009-FREBON-052 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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