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PhD in Organic Chemistry in LCMT (Caen, France) (Male/Female)

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR6507-STEPER-001
Workplace : CAEN
Date of publication : Wednesday, February 12, 2020
Scientific Responsible name : Stephane Perrio
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The development of catalytic reaction, especially making use of new environmentally benign organocatalysts, is of current interest in sustainable chemistry. Moreover, the construction of chiral molecules remains an important current synthetic approach to provide new 3D-molecules to medicinal chemists. Accordingly, the proposed project deals with novel synthetic methodologies in organic chemistry. It aims at developing new selective organocatalytic transformations (including asymmetric versions), based on the activation of electron deficient allenes with anionic sulfur nucleophiles and by implementing unprecedented cooperative catalytic ion-pairing approaches with ammonium cations. The search for novel reactivities in organic synthesis to access chiral scaffolds will be the main purpose of this project. The project will be conducted by Dr. Stéphane Perrio, within the group of Pr. Annie-Claude Gaumont (Caen, France), in close collaboration with Dr. Sylvain Oudeyer and Dr. Jean-François Brière (Laboratory COBRA, University of Rouen Normandy, France).
For recent references related to the project, see:
(1) T. Martzel, J.-F. Lohier, A.-C. Gaumont, J.-F. Brière, S. Perrio, Adv. Synth. Catal. 2017, 359, 96.
(2) Martzel, T.; Lohier, J.-F.; Gaumont, A.-C.; Brière, J.-F. and Perrio, S. Adv. Synth. Catal. 2018, 360, 2696.
(3) Martzel, T.; Lohier, J.-F.; Gaumont, A.-C.; Brière, J.-F. and Perrio, S. Eur. J. Org. Chem. 2018, 5069.
Key words : organocatalysis, asymmetric synthesis, sulfur chemistry, heterocycles, allenes, ion-pairing catalysis

Work Context

Labex Synorg/Normandy Region funding.
The project will be conducted in LCMT (Caen) in collaboration with Dr. Sylvain Oudeyer and Dr. Jean-François Brière (Laboratory COBRA, University of Rouen Normandy, France).
The applicants should have a strong background in organic synthesis, and skills in standard characterization tools (multinuclear NMR, IR and MS spectrometry). Candidates showing a real interest in synthetic methodology will also be distinctly appreciated.

Additional Information

Documents:
– a detailed CV with 2 contacts for recommendations,
– a brief motivation letter
An interview is also planned in the recruitment process.

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