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Reference : UMR6014-DOMCAH-001
Workplace : MONT ST AIGNAN
Date of publication : Tuesday, July 13, 2021
Scientific Responsible name : Dominique Cahard
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 January 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The pentafluorosulfanyl group is a truly new functional groups introduced to organic chemists in the last decades. The paucity of hypervalent fluorinated sulfur-containing molecules is the result of unfavourable factors that are the poor availability of reagents for the introduction of the SF5 group, the lack of activation modes for SF5Cl or the notoriously inertness SF6, the absence of generalized methods to access λ6-pentafluorosulfanes, and thus a poor availability of SF5-containing building blocks, specifically aliphatic SF5 ones. We propose several levers of innovation to tackle the major bottlenecks that impede the bright future of SF5 chemistry. We hypothesize that new activation modes together with the design of safe reagents can be used to generate an extensive portfolio of novel SF5 compounds (WP1). Successful implementation of this fundamental research will create a sound foundation for the
asymmetric construction of novel chiral non-racemic molecular architectures (WP2).
ANR Sulfive 2021-2025 project based at UMR 6014 COBRA in Mont Saint Aignan in partnership with Dr Vincent Bizet of UMR 7042 LIMA at the University of Strasbourg (Mulhouse campus).
Constraints and risks
Recruitment for a PhD thesis to start in January 2022.
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