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Reference : UMR5628-ANNDUC-001
Workplace : GRENOBLE
Date of publication : Thursday, November 21, 2019
Scientific Responsible name : MIGLIORINI Elisa
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 January 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
This PhD aims to decipher the structure-function relationship between growth factors (GFs) and glycosaminoglycans (GAGs) in the context of endochondral bone formation. The project, highly interdisciplinary, will first explore at the molecular level the interactions between GAGs and GFs to decipher the effect of the GAG structure on GFs binding affinity. Secondly the effect of different GAG¬–GFs affinities will be tested on cellular cultures and in vivo mice models. For that biomimetic streptavidin platforms are engineered. These platforms present surface-grafted GAGs and adhesion ligands, for molecular and cellular studies.
The candidate will be a master or engineer student from biomedical engineering school, biochemistry, biophysical chemistry or related subject. We are looking for a student with a positive attitude towards learning new techniques. An interdisciplinary background on biology and material science will be highly appreciated. Good level of written and spoken English are necessary as well a good attitude towards team working
The three year PhD will start at LMGP in Grenoble, to then be pursued to CEA, Grenoble since the team will move to this new laboratory. During the PhD thesis the student will strongly collaborate with R. Vivès group in IBS, Grenoble and A. Vortkamp, Duisburg-Essen, Germany. Secondments in both laboratories are foreseen to foster the collaboration and the exchange between the three laboratories.
Constraints and risks
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