Informations générales
Intitulé de l'offre : PhD Thesis (M/F) - Formulation of lipid coatings for oral administration of supersaturated forms of Praziquantel (H/F)
Référence : UMR5623-MURBLA-006
Nombre de Postes : 1
Lieu de travail : TOULOUSE
Date de publication : lundi 5 mai 2025
Type de contrat : CDD Doctorant
Durée du contrat : 36 mois
Date de début de la thèse : 15 juillet 2025
Quotité de travail : Complet
Rémunération : 2200 gross monthly
Section(s) CN : 11 - Matière molle : synthèse, élaboration, assemblages, structure, propriétés, fonctions
Description du sujet de thèse
According to the World Health Organization, schistosomiasis is a global parasitic disease affecting over 250 million people, for which Praziquantel is the most widely used drug. It is a compound with a good safety window, but its low efficacy against the juvenile stages of the parasites and highly irregular pharmacokinetic profiles limit its effectiveness. Against this background, the aim of this project is to develop new lipid formulations of supersaturated forms of praziquantel, in order to improve its stability and bioavailability.
The main objective of this PhD Thesis will therefore be to develop a new formulation based on supersaturated forms of Praziquantel.
Tasks will include:
- Implementation of lipid coatings and their physicochemical characterization (light scattering, electron microscopy, thermal analysis, etc.)
- Evaluation of coating disintegration in water
- Study of the crystallization mechanism and its modeling by QSPR to optimize the system
Contexte de travail
The offer comes from the SMODD team, part of the SOFTMAT laboratory (CNRS UMR 5623, Toulouse), and is part of the multidisciplinary GALANTH project funded by the ANR, which is the result of collaboration between the SOFTMAT, RAPSODEE and MEDIS laboratories, and the Oswaldo Cruz Foundation in Brazil (FIOCRUZ).
The SMODD team has solid, internationally-recognized experience in formulation using systems derived from soft matter; research that combines synthesis engineering and physicochemical characterization of innovative self-assemblies with a sustainable development approach. In particular, the SMODD team designs formulations for cosmetic and pharmaceutical applications.
Contraintes et risques
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